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dc.contributor.authorSábado, J.
dc.contributor.authorCasanovas i Llorens, Anna
dc.contributor.authorRodrigo, H.
dc.contributor.authorArqué, G.
dc.contributor.authorEsquerda Colell, Josep
dc.date.accessioned2016-01-26T19:20:02Z
dc.date.issued2015-12-01
dc.identifier.issn0306-4522
dc.identifier.urihttp://hdl.handle.net/10459.1/49398
dc.description.abstractPrevious reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). Cross-reactivity could be caused by the abnormal exposure of an epitope located in the inner hydrophobic region of SOD1 that shared structural homology with the P2X4-immunizing peptide. We had previously raised antibodies against human SOD1 epitope mimicked by the P2X4 immunizing peptide. One of these antibodies, called AJ10, was able to recognize mutant/misfolded forms of ALS-linked mutant SOD1. Here, we used the AJ10 antigen as a vaccine to target neurotoxic species of mutant SOD1 in a slow mouse model of ALS. However, the obtained results showed no improvement in life span, disease onset or weight loss in treated animals; we observed an increased microglial neuroinflammatory response and high amounts of misfolded SOD1 accumulated within spinal cord neurons after AJ10 immunization. An increase of immunoglobulin G deposits was also found due to the treatment. Finally, a significantly worse clinical evolution was displayed by an impairment on motor function as a consequence of AJ10 peptide immunization
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.neuroscience.2015.09.027
dc.relation.ispartofNeuroscience, 2015, vol. 310, p. 38-50
dc.rights(c) Elsevier, 2015
dc.subject.classificationEsclerosi lateral amiotròfica
dc.subject.classificationMicròglia
dc.subject.classificationImmunoteràpia
dc.subject.classificationInflamació
dc.subject.otherAmyotrophic lateral sclerosis
dc.subject.otherMicroglia
dc.subject.otherImmunotheraphy
dc.subject.otherInflammation
dc.titleAdverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2016-01-26T19:20:02Z
dc.identifier.idgrec023655
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2015.09.027
dc.date.embargoEndDate2025-01-01


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