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Effect of defunctionalization on colon carcinogenesis in the rat

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Issue date
2006
Author
Pérez-Holanda Fernández, Sergio
Rodrigo, Luis
Viñas Salas, Joan
Piñol Felis, Carme
Ildefonso, C.
Suggested citation
Pérez-Holanda Fernández, Sergio; Rodrigo, Luis; Viñas Salas, Joan; Piñol Felis, Carme; Ildefonso, C.; . (2006) . Effect of defunctionalization on colon carcinogenesis in the rat. Revista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649. http://hdl.handle.net/10459.1/49278.
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Abstract
Objective: to examine the effect of fecal absence on experimental colon carcinogenesis in both male and female rats. Material and methods: a total of 138 10-week-old Sprague- Dawley, male and female rats were divided into five groups: A) 20 rats, no treatment; B) 26 rats, colonic defunctionalization; C) 30 rats, 18 weekly doses of dimethylhydrazine (DMH), 21 mg/kg body weight each, from the beginning of the study; D) 20 rats, ethylen-diamine-tetraacetic acid for 18 weeks; and E) 42 rats, same surgical procedure as rats in group B plus DMH injections at the same doses as rats in group C. Animals were sacrificed after 25-27 weeks. Number of tumors, their location, and pathological findings were all compared between groups. Results: no tumors developed in the dimethylhydrazine-free groups. No differences were obtained either in number of tumors or tumors per rat for group C as compared to group E. Fecal absence was associated with smaller-sized tumors (p = 0.007), greater numbers of non-mucinous tumors (p = 0.00009), better differentiation (p = 0.0054), and lesser penetration into the wall (p = 0.015) for group E as compared to group C. In the dimethylhydrazine group, fecal absence altered the number of tumors developing in males as compared to female rats (p = 0.025). Moreover, this fecal absence showed no inhibitory effect on right colonic tumors (p = 0.0065). Conclusions: fecal absence alters the DMH-carcinogenic pattern in the defunctionalized colon when using an experimental model in both male and female rats.
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http://hdl.handle.net/10459.1/49278
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Revista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649
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  • Articles publicats (Cirurgia) [153]
  • Articles publicats (Medicina) [456]

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