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Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer

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Issue date
2012
Author
Valls i Bautista, Cristina
Piñol Felis, Carme
Reñé Espinet, Josep Maria
Buenestado Garcia, Juan
Viñas Salas, Joan
Suggested citation
Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan; . (2012) . Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer. Revista Española de Enfermedades Digestivas, 2012, vol. 104, núm. 10, p. 530-536. https://doi.org/10.4321/S1130-01082012001000005.
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Abstract
Background: colorectal cancer is the third cancer cause of death in Spain. It is important to investigate new tumoral markers for early diagnosis, disease monitoring and prevention strategies. Telomeres protect the chromosome from degradation by nucleases and endto- end fusion. The progressive loss of the telomeric ends of chromosomes is an important mechanism in the timing of human cellular aging. Telomeric Repeat Factor 1 (TRF1) is a protein that binds at telomere ends. Purpose: to measure the concentrations of TRF1 and the relationships among telomere length, telomerase activity, and TRF1 levels in tumor and normal colorectal mucosa. Method: from normal and tumoral samples of 83 patients who underwent surgery for colorectal cancer we analyzed TRF1 protein concentration by Western Blot, telomerase activity, by the fluorescent- telomeric repeat amplification protocol assay and telomere length by Southern Blot. Results: high levels of TRF1 were observed in 68.7% of tumor samples, while the majority of normal samples (59%) showed negative or weak TRF1 concentrations. Among the tumor samples, telomere length was significantly associated with TRF1 protein levels (p = 0.023). Conclusions: a relationship was found between telomere length and TRF1 abundance protein in tumor samples, which means that TRF1 is an important factor in the tumor progression and maybe a diagnostic factor.
URI
http://hdl.handle.net/10459.1/49253
DOI
https://doi.org/10.4321/S1130-01082012001000005
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Revista Española de Enfermedades Digestivas, 2012, vol. 104, núm. 10, p. 530-536
European research projects
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  • Articles publicats (Medicina) [329]
  • Articles publicats (Cirurgia) [120]

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  • Telomere length is a prognostic factor for overall survival in colorectal cancer 

    Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Wiley, 2011)
    Aim The aim of this study was to determine whether telomere length is an independent prognostic factor for the prevention and survival of colorectal cancer. Method Terminal restriction fragment (TRF) length was determined ...
  • Telomerase activity and telomere length in the colorectal polyp-carcinoma sequence 

    Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Sociedad Española de Patología DigestivaArán Ediciones, 2009)
    Objective: the role of telomerase activity and telomere length in the adenoma-carcinoma sequence of colon carcinogenesis has not been well established. The objective of this study was to determine telomerase activity and ...
  • In colon cancer, normal colon tissue and blood cells have altered telomere lengths 

    Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Wiley Online Library, 2015-04-17)
    Background: Telomere length (TL) shortened occurs in colorectal carcinogenetic process. Our objective is to determine if it is only a local fact or there are alterations in normal colon cells and in other body cells. ...

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