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dc.contributor.authorArjó Pont, Gemma
dc.contributor.authorCapell Capell, Teresa
dc.contributor.authorMatias-Guiu, Xavier
dc.contributor.authorZhu, Changfu
dc.contributor.authorChristou, Paul
dc.contributor.authorPiñol Felis, Carme
dc.date.accessioned2015-11-25T11:55:36Z
dc.date.issued2012-12
dc.identifier.issn1467-7644
dc.identifier.urihttp://hdl.handle.net/10459.1/49058
dc.description.abstractMultivitamin corn is a novel genetically engineered variety that simultaneously produces high levels of beta-carotene, ascorbate and folate, and therefore has the potential to address simultaneously multiple micronutrient deficiencies caused by the lack of vitamins A, B9 and C in developing country populations. As part of the development process for genetically engineered crops and following European Food Safety Authority (EFSA) recommendations, multivitamin corn must be tested in whole food/feed sub-chronic animal feeding studies to ensure there are no adverse effects, and potential allergens must be identified. We carried out a 28-day toxicity assessment in mice, which showed no short-term sub-acute evidence of diet-related adverse health effects and no difference in clinical markers (food consumption, body weight, organ/tissue weight, haematological and biochemical blood parameters and histopathology) compared to mice fed on a control diet. A subsequent 90-day sub-chronic feeding study again showed no indications of toxicity compared to mice fed on control diets. Our data confirm that diets enriched with multivitamin corn have no adverse effects on mice, do not induce any clinical signs of toxicity and do not contain known allergens.ca_ES
dc.description.sponsorshipThis work was supported by the Ministry of Science and Innovation, Spain (BFU2007-61413 and BIO2007-30738-E) and European Research Council Advanced Grant (BIOFORCE) to PC. We thank Ana Martinez and Laura Arcal for excellent technical assistance and the entire team in the laboratory of Applied Plant Biotechnology at the Universitat de Lleida for stimulating discussions.
dc.language.isoengca_ES
dc.publisherWiley-Blackwellca_ES
dc.publisherJohn Wiley & Sons
dc.relationMIECI/PN2004-2007/BFU2007-61413
dc.relationMICINN/PN2004-2007/BIO2007-30738-E
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1111/j.1467-7652.2012.00730.xca_ES
dc.relation.ispartofPlant Biotechnology Journal, 2012, vol.10, num. 9, p. 1026-1034ca_ES
dc.rights(c) Wiley-Blackwell, 2013ca_ES
dc.subjectGenetically engineered cornca_ES
dc.subjectSafety assessmentca_ES
dc.subjectSub-chronic toxicityca_ES
dc.subject.otherEnginyeria genèticaca_ES
dc.titleMice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicityca_ES
dc.typearticleca_ES
dc.identifier.idgrec018551
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1111/j.1467-7652.2012.00730.x
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232933
dc.date.embargoEndDate10000-01-01


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