Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity
Fecha de publicación2012-12
Arjó Pont, Gemma
MetadatosMostrar el registro completo del ítem
Multivitamin corn is a novel genetically engineered variety that simultaneously produces high levels of beta-carotene, ascorbate and folate, and therefore has the potential to address simultaneously multiple micronutrient deficiencies caused by the lack of vitamins A, B9 and C in developing country
populations. As part of the development process for genetically engineered crops and following European Food Safety Authority (EFSA) recommendations, multivitamin corn must be tested in whole food/feed sub-chronic animal feeding studies to ensure there are no adverse effects, and potential allergens must be identified. We carried out a 28-day toxicity assessment in mice, which showed no short-term sub-acute evidence of diet-related adverse health effects and no difference in clinical markers (food consumption, body weight, organ/tissue weight, haematological and biochemical blood parameters and histopathology) compared to mice fed on a control diet. A subsequent 90-day sub-chronic feeding study again showed no indications of toxicity compared to mice fed on control diets. Our data confirm that diets enriched with multivitamin corn have no adverse effects on mice, do not induce any clinical signs of toxicity and do not contain known allergens.
Es parte dePlant Biotechnology Journal, 2012, vol.10, num. 9, p. 1026-1034
Showing items related by title, author, creator and subject.
Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...
High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies Changfu, Zhu; Sanahuja Solsona, Georgina; Yuan, Dawei; Farré Martinez, Gemma; Arjó Pont, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Banakar, Raviraj; Bai, Chao; Pérez Massot, Eduard; Bassie Rene, Ludovic; Capell Capell, Teresa; Christou, Paul (Wiley Open Access, 2013)Antioxidants are protective molecules that neutralize reactive oxygen species and prevent oxidative damage to cellular components such as membranes, proteins and nucleic acids, therefore reducing the rate of cell death ...