Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity

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Issue date
2012-12
Author
Arjó Pont, Gemma
Capell Capell, Teresa
Matias-Guiu, Xavier
Zhu, Changfu
Christou, Paul
Piñol Felis, Carme
Suggested citation
Arjó Pont, Gemma; Capell Capell, Teresa; Matias-Guiu, Xavier; Zhu, Changfu; Christou, Paul; Piñol Felis, Carme; . (2012) . Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity. Plant Biotechnology Journal, 2012, vol.10, num. 9, p. 1026-1034. https://doi.org/10.1111/j.1467-7652.2012.00730.x.
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Abstract
Multivitamin corn is a novel genetically engineered variety that simultaneously produces high levels of beta-carotene, ascorbate and folate, and therefore has the potential to address simultaneously multiple micronutrient deficiencies caused by the lack of vitamins A, B9 and C in developing country
populations. As part of the development process for genetically engineered crops and following European Food Safety Authority (EFSA) recommendations, multivitamin corn must be tested in whole food/feed sub-chronic animal feeding studies to ensure there are no adverse effects, and potential allergens must be identified. We carried out a 28-day toxicity assessment in mice, which showed no short-term sub-acute evidence of diet-related adverse health effects and no difference in clinical markers (food consumption, body weight, organ/tissue weight, haematological and biochemical blood parameters and histopathology) compared to mice fed on a control diet. A subsequent 90-day sub-chronic feeding study again showed no indications of toxicity compared to mice fed on control diets. Our data confirm that diets enriched with multivitamin corn have no adverse effects on mice, do not induce any clinical signs of toxicity and do not contain known allergens.
URI
http://hdl.handle.net/10459.1/49058
DOI
https://doi.org/10.1111/j.1467-7652.2012.00730.x
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Plant Biotechnology Journal, 2012, vol.10, num. 9, p. 1026-1034
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