Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

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2012
Author
Naudí i Farré, Alba
Jové Font, Mariona
Ayala Jové, Ma. Victoria (Maria Victoria)
Cassanyé, Anna
Serrano Casasola, José Carlos Enrique
Gonzalo Benito, Hugo
Boada Pallàs, Jordi
Prat Corominas, Joan
Portero Otín, Manuel
Pamplona Gras, Reinald
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Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; ... Pamplona Gras, Reinald. (2012) . Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress. Experimental Diabetes Research, 2012, vol. 2012. https://doi.org/10.1155/2012/696215.
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Abstract
Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting severalmetabolic and
signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage.
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http://hdl.handle.net/10459.1/49051
DOI
https://doi.org/10.1155/2012/696215
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Experimental Diabetes Research, 2012, vol. 2012
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