Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

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2012Author
Gonzalo Benito, Hugo
Prat Corominas, Joan
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Naudí i Farré, Alba;
Jové Font, Mariona;
Ayala Jové, Ma. Victoria (Maria Victoria);
Cassanyé, Anna;
Serrano Casasola, José Carlos Enrique;
Gonzalo Benito, Hugo;
...
Pamplona Gras, Reinald.
(2012)
.
Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress.
Experimental Diabetes Research, 2012, vol. 2012.
https://doi.org/10.1155/2012/696215.
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Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence
suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a
maladaptive response by affecting severalmetabolic and signaling pathways involved in the pathophysiology of cellular dysfunction
and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free
radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the
resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies
for diabetes focused to the prevention of mitochondrial oxidative damage.
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Experimental Diabetes Research, 2012, vol. 2012European research projects
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