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dc.contributor.authorGutierrez, Humberto
dc.contributor.authorHale, Valerie A.
dc.contributor.authorDolcet Roca, Xavier
dc.contributor.authorDavies, Alun M.
dc.date.accessioned2015-11-19T13:03:20Z
dc.date.available2015-11-19T13:03:20Z
dc.date.issued2005-04
dc.identifier.issn0950-1991
dc.identifier.urihttp://hdl.handle.net/10459.1/49010
dc.description.abstractThe proper growth and elaboration of neural processes is essential for the establishment of a functional nervous system during development and is an integral feature of neural plasticity throughout life. Nuclear factor-kappa B (NF-kappa B) is classically known for its ubiquitous roles in inflammation, immune and stress-related responses and regulation of cell survival in all tissues, including the nervous system. NF-kappa B participation in other cellular processes remains poorly understood. Here we report a mechanism for controlling the growth of neural processes in developing peripheral and central neurons involving the transcription factor NF-kappa B. Inhibiting NF-kappa B activation with super-repressor I kappa B-alpha, BAY 11 7082 (I kappa B-alpha phosphorylation inhibitor) or N-acetyl-Leu-Leu-norleucinal (proteosomal degradation inhibitor), or inhibiting NF-kappa B transcriptional activity with kappa B decoy DNA substantially reduced the size and complexity of the neurite arbors of sensory neurons cultured with brain-derived neurotrophic factor while having no effect on their survival. NF-kappa B exerted this effect during a restricted period of development following the phase of naturally occurring neuronal death when the processes and connections of the remaining neurons are extensively modified and refined. Inhibiting NF-kappa B activation or NF-kappa B transcriptional activity in layer 2 pyramidal neurons in postnatal somatosensory cortical slices reduced dendritic arbor size and complexity. This function of NF-kappa B has important implications for neural development and may provide an explanation for reported involvement of NF-kappa B in learning and memory.ca_ES
dc.language.isoengca_ES
dc.publisherCompany of Biologists Ltd.ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1242/dev.01702ca_ES
dc.relation.ispartofDevelopment, 2005, vol. 32, núm. 7, p. 1713-1726ca_ES
dc.rights(c) Company of Biologists Ltd., 2005ca_ES
dc.subjectNF-kappa B
dc.subjectAxon
dc.subjectDendrite
dc.subjectPyramidal neuron
dc.subjectSensory neuron
dc.subject.otherNeurones sensorials
dc.subject.otherSistema nerviós
dc.titleNF-κB signalling regulates the growth of neural processes in the developing PNS and CNSca_ES
dc.typearticleca_ES
dc.identifier.idgrec021108
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1242/dev.01702


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