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dc.contributor.authorVenditti, Paola
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorAyala Jové, Ma. Victoria (Maria Victoria)
dc.contributor.authorRosa, R. de
dc.contributor.authorCaldarone, G.
dc.contributor.authorDi Meo, S.
dc.date.accessioned2015-11-19T12:04:33Z
dc.date.available2015-11-19T12:04:33Z
dc.date.issued2006-03
dc.identifier.issn0022-0949
dc.identifier.urihttp://hdl.handle.net/10459.1/49007
dc.description.abstractThyroid hormone-induced increase in metabolic rates is often associated with increased oxidative stress. The aim of the present study was to investigate the contribution of iodothyronines to liver oxidative stress in the functional hyperthyroidism elicited by cold, using as models cold-exposed and 3,5,3'-triiodothyronine (T-3)- or thyroxine (T-4)-treated rats. The hyperthyroid state was always associated with increases in both oxidative capacity and oxidative damage of the tissue. The most extensive damage to lipids and proteins was found in T-3-treated and cold-exposed rats, respectively. Increase in oxygen reactive species released by mitochondria and microsomes was found to contribute to tissue oxidative damage, whereas the determination of single antioxidants did not provide information about the possible contribution of a reduced effectiveness of the antioxidant defence system. Indeed, liver oxidative damage in hyperthyroid rats was scarcely related to levels of the liposoluble antioxidants and activities of antioxidant enzymes. Conversely, other biochemical changes, such as the degree of fatty acid unsaturation and hemoprotein content, appeared to predispose hepatic tissue to oxidative damage associated with oxidative challenge elicited by hyperthyroid state. As a whole, our results confirm the idea that T-3 plays a key role in metabolic changes and oxidative damage found in cold liver. However, only data concerning changes in glutathione peroxidase activity and mitochondrial protein content favour the idea that dissimilarities in effects of cold exposure and T-3 treatment could depend on differences in serum levels of T-4.ca_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Science and Technology (BFI2003-01287) and the Generalitat of Catalunya (2001SGR00311) and Italian Ministry of University and Scientific and Technological Research.
dc.language.isoengca_ES
dc.publisherCompany of Biologists Ltd.ca_ES
dc.relationMICYT/PN2000-2003/BFI2003-01287
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1242/jeb.02045ca_ES
dc.relation.ispartofJournal of Experimental Biology, 2006, vol. 209, núm. 5, p. 817-825ca_ES
dc.rights(c) Company of Biologists Ltd., 2006ca_ES
dc.subjectCold exposureca_ES
dc.subjectAntioxidant capacityca_ES
dc.subjectFree radicalca_ES
dc.subjectLipid peroxidationca_ES
dc.subject.otherAntioxidantsca_ES
dc.subject.otherRadicals lliuresca_ES
dc.titleDifferential effects of experimental and cold-induced hyperthyroidism on factors inducing rat liver oxidative damageca_ES
dc.typearticleca_ES
dc.identifier.idgrec008761
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1242/jeb.02045


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