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dc.contributor.authorNaudí i Farré, Alba
dc.contributor.authorJové Font, Mariona
dc.contributor.authorAledo, Juan Carlos
dc.contributor.authorAyala Jové, Ma. Victoria (Maria Victoria)
dc.contributor.authorCabré Cucó, Rosanna
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorBarja, Gustavo
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2015-11-18T11:17:32Z
dc.date.available2015-11-18T11:17:32Z
dc.date.issued2013
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10459.1/48985
dc.description.abstractdetermination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations, peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevityca_ES
dc.description.sponsorshipWe acknowledge funding from the Spanish Ministry of Science and Innovation (CGL2010-18124) to J.C.A.; from the Spanish Ministry of Health (PI11-01532) to M.P.O.; and from the Spanish Ministry of Science and Innovation (BFU2009-11879/BFI), the Generalitat of Catalonia (2009SGR735), and the La MaratoTV3 Foundation to R.P. R.C. was supported by a Generalitat of Catalonia Predoctoral Fellowship. We thank David Argiles for excellent technical assistance. We thank Dr. Montserrat Rué for her support in statistical analyses.
dc.language.isoengca_ES
dc.publisherNature Publishing Groupca_ES
dc.relationMICINN/PN2008-2011/CGL2010-18124
dc.relationMICINN/PN2008-2011/PI11-01532
dc.relationMICINN/PN2008-2011/BFU2009-11879/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1038/srep03346ca_ES
dc.relation.ispartofScientific Reports, 2013, vol. 3, p. 1-10ca_ES
dc.rightscc-by-nc-nd (c) Jové Font, Mariona et al., 2013ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectLongevityca_ES
dc.subjectPlasma long-chainca_ES
dc.subjectMetabolismca_ES
dc.titlePlasma long-chain free fatty acids predict mammalian longevityca_ES
dc.typearticleca_ES
dc.identifier.idgrec020183
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1038/srep03346


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cc-by-nc-nd (c) Jové Font, Mariona et al., 2013
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Jové Font, Mariona et al., 2013