Plasma long-chain free fatty acids predict mammalian longevity

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2013Author
Aledo, Juan Carlos
Barja, Gustavo
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Naudí i Farré, Alba;
Jové Font, Mariona;
Aledo, Juan Carlos;
Ayala Jové, Ma. Victoria (Maria Victoria);
Cabré Cucó, Rosanna;
Portero Otín, Manuel;
...
Pamplona Gras, Reinald.
(2013)
.
Plasma long-chain free fatty acids predict mammalian longevity.
Scientific Reports, 2013, vol. 3, p. 1-10.
https://doi.org/10.1038/srep03346.
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determination of their longevity. In the present work, the use of high-throughput technologies allowed us to
determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to
120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the
animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer
the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations,
peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These
results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity
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Scientific Reports, 2013, vol. 3, p. 1-10European research projects
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