Plasma long-chain free fatty acids predict mammalian longevity

Thumbnail
View/Open
Issue date
2013
Author
Naudí i Farré, Alba
Jové Font, Mariona
Aledo, Juan Carlos
Ayala Jové, Ma. Victoria (Maria Victoria)
Cabré Cucó, Rosanna
Portero Otín, Manuel
Barja, Gustavo
Pamplona Gras, Reinald
Suggested citation
Naudí i Farré, Alba; Jové Font, Mariona; Aledo, Juan Carlos; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; ... Pamplona Gras, Reinald. (2013) . Plasma long-chain free fatty acids predict mammalian longevity. Scientific Reports, 2013, vol. 3, p. 1-10. https://doi.org/10.1038/srep03346.
Impact

Google Scholar logo  Google Scholar
Share
Export to Mendeley
Metadata
Show full item record
Abstract
determination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations, peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity
URI
http://hdl.handle.net/10459.1/48985
DOI
https://doi.org/10.1038/srep03346
Is part of
Scientific Reports, 2013, vol. 3, p. 1-10
Collections

The following license files are associated with this item:

cc-by-nc-nd (c) Jové Font, Mariona et al., 2013
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Jové Font, Mariona et al., 2013