Plasma long-chain free fatty acids predict mammalian longevity

Naudí i Farré, Alba; Jové Font, Mariona; Aledo, Juan Carlos; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald

doi:https://doi.org/10.1038/srep03346

View/Open

020183 (1.299Mb)

Issue date

2013

Author

Naudí i Farré, Alba

Jové Font, Mariona

Aledo, Juan Carlos

Ayala Jové, Ma. Victoria (Maria Victoria)

Cabré Cucó, Rosanna

Portero Otín, Manuel

Barja, Gustavo

Pamplona Gras, Reinald

Abstract

determination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 years. The non-targeted approach revealed a specie-specific lipidomic profile that

accurately predicts the animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations, peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity

URI

http://hdl.handle.net/10459.1/48985

DOI

https://doi.org/10.1038/srep03346

Is part of

Scientific Reports, 2013, vol. 3, p. 1-10

Collections

The following license files are associated with this item:

Creative Commons

Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Jové Font, Mariona et al., 2013