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dc.contributor.authorPurroy Garcia, Francisco
dc.contributor.authorSuárez-Luis, Idalmis
dc.contributor.authorMauri-Capdevila, Gerard
dc.contributor.authorCambray Carner, Serafí
dc.contributor.authorFarré, Joan
dc.contributor.authorSanahuja Montesinos, Jordi
dc.contributor.authorPiñol Ripoll, Gerard
dc.contributor.authorQuilez Martínez, Alejandro
dc.contributor.authorGonzález Mingot, Cristina
dc.contributor.authorBegué Gómez, Robert
dc.contributor.authorGil, M. Isabel
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorBenabdelhak Abbou, Ikram
dc.date.accessioned2015-11-17T19:32:53Z
dc.date.issued2014-06-25
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/10459.1/48981
dc.description.abstractBACKGROUND AND PURPOSE: The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum biomarkers measured in consecutive TIA patients. METHODS: The concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha, neuron-specific enolase, high-sensitivity C-reactive protein, IL-1-α and the N-terminal pro-B type natriuretic peptide (NT-proBNP) were quantified in the serum of 140 patients with TIA and 44 non-stroke subjects. Measurements were performed at different times throughout evolution: within 24 h of symptoms onset and at days 7 and 90. RESULTS: With the exception of IL-6, all biomarkers were higher in TIA patients than in controls. NT-proBNP was significantly related to the presence or new diagnosis of AF at all time points analyzed. Furthermore, the baseline NT-proBNP level was significantly higher than values at the 7-day and 90-day follow-up. For this reason, different cut-off values were obtained at different times: 313 pg/ml at baseline [odds ratio (OR) = 18.99, P < 0.001], 181 pg/ml at 7 days (OR = 11.4, P = 0.001) and 174 pg/ml (OR = 8.46, P < 0.001) at 90 days. CONCLUSION: High levels of NT-proBNP determined during the first 3 months after a TIA were associated with AF. Consequently, this biomarker may be useful to reclassify undetermined TIA patients as having disease of CE.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1111/ene.12222
dc.relation.ispartofEuropean Journal of Neurology, 2014, vol. 21, num. 4, p. 679-683
dc.rights(c) Wiley, 2014
dc.subject.classificationIsquèmia
dc.subject.otherIschemia
dc.titleN-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-11-17T19:32:54Z
dc.identifier.idgrec019926
dc.type.versionpublishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.1111/ene.12222
dc.date.embargoEndDate2025-01-01


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