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dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorJové Font, Mariona
dc.contributor.authorRodríguez, M. Mar
dc.contributor.authorPérez, Daniel
dc.contributor.authorChaves, Felipe Javier
dc.contributor.authorEsteve, Eduardo
dc.contributor.authorMarin-Garcia, Pablo
dc.contributor.authorXifra, Gemma
dc.contributor.authorVendrell, Joan
dc.contributor.authorRicart, Wifredo
dc.contributor.authorChacón, Matilde R.
dc.contributor.authorFernández Real, José Manuel
dc.description.abstractThe human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.ca_ES
dc.publisherNature Publishing Groupca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofScientific Reports, 2015, vol. 5, núm. 14600ca_ES
dc.rightscc-by (c) Rodríguez, M. Mar et al., 2015ca_ES
dc.titleObesity changes the human gut mycobiomeca_ES

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cc-by (c) Rodríguez, M. Mar et al., 2015
Except where otherwise noted, this item's license is described as cc-by (c) Rodríguez, M. Mar et al., 2015