Obesity changes the human gut mycobiome

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2015Author
Rodríguez, M. Mar
Pérez, Daniel
Chaves, Felipe Javier
Esteve, Eduardo
Marin-Garcia, Pablo
Xifra, Gemma
Vendrell, Joan
Ricart, Wifredo
Chacón, Matilde R.
Fernández Real, José Manuel
Suggested citation
Portero Otín, Manuel;
Pamplona Gras, Reinald;
Jové Font, Mariona;
Rodríguez, M. Mar;
Pérez, Daniel;
Chaves, Felipe Javier;
...
Fernández Real, José Manuel.
(2015)
.
Obesity changes the human gut mycobiome.
Scientific Reports, 2015, vol. 5, núm. 14600.
https://doi.org/10.1038/srep14600.
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The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.
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Scientific Reports, 2015, vol. 5, núm. 14600European research projects
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Except where otherwise noted, this item's license is described as cc-by (c) Rodríguez, M. Mar et al., 2015
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