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dc.contributor.authorMacià Armengol, Anna
dc.contributor.authorHerreros Danés, Judit
dc.contributor.authorMartí Laborda, Rosa Ma.
dc.contributor.authorCantí Nicolás, Carles
dc.date.accessioned2015-09-16T10:40:07Z
dc.date.available2015-09-16T10:40:07Z
dc.date.issued2015
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10459.1/48712
dc.description.abstractThe remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular facet of these adaptive changes is the alteration of Ca2+ fluxes through the plasma membrane, as described in several studies. In this review, we summarize the current knowledge about the expression of different Ca2+ channels in the plasma membrane of melanoma cells and its impact on oncogenic Ca2+ signaling. In the last few years, new molecular components of Ca2+ influx pathways have been identified in melanoma cells. In addition, new links between Ca2+ homeostasis and specific cell processes important in melanoma tumor progression have been unveiled. Thus, not only do Ca2+ channels appear to have a potential as prognostic markers, but their pharmacological blockade or gene silencing is hinted as interesting therapeutic approaches.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.2340/00015555-1997
dc.relation.ispartofBiomed Research International, 2015, vol. 2015, p. 587135
dc.rightscc-by (c) Macià Armengol, Anna et al., 2015
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.subject.classificationMelanoma
dc.subject.classificationCèl·lules canceroses
dc.subject.otherMelanoma
dc.subject.otherCancer cells
dc.titleCalcium channel expression and applicability as targeted therapies in melanoma
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-09-16T10:40:08Z
dc.identifier.idgrec023205
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.2340/00015555-1997


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cc-by (c) Macià Armengol, Anna et al., 2015
Except where otherwise noted, this item's license is described as cc-by (c) Macià Armengol, Anna et al., 2015