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dc.contributor.authorRubinat, Esther
dc.contributor.authorOrtega, Emilio
dc.contributor.authorTraveset Maeso, Alicia
dc.contributor.authorArcidiacono, Maria V.
dc.contributor.authorAlonso, Núria
dc.contributor.authorBetriu i Bars, M. Àngels
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorHernández García, Marta
dc.contributor.authorSoldevila, Jordi
dc.contributor.authorPuig-Domingo, Manuel
dc.contributor.authorJurjo Campo, Carmen
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorMauricio Puente, Dídac
dc.date.accessioned2015-09-15T11:56:50Z
dc.date.issued2015-06-00
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/10459.1/48707
dc.description.abstractObjective: We hypothesize that in type 1 diabetes vasa vasorum (VV) are affected by microangiopathic changes. For this purpose, we assessed the status of the VV signal in patients with type 1 diabetes. Methods: The VV signal at the arterial adventitia of the common carotid artery was evaluated by contrast-enhanced ultrasound imaging. The VV contrast agent signal was quantified in an plaque-free arterial segment as the ratio of the adventitial signal and that of the lumen of the artery. We studied 113 type 1 diabetic patients, 60 with and 53 without retinopathy and without known cardiovascular disease, and a group of 78 non-diabetic subjects free of cardiovascular risk factors. All study subjects underwent a clinical evaluation. Results: The mean ± standard deviation VV signal of healthy subjects was 0.562 ± 0.135. Type 1 diabetic patients showed a higher adventitial VV signal (0.723 ± 0.128) than non-diabetic subjects (P < 0.0001). After adjustment for cardiovascular risk confounders, this difference remained significant. No differences in VV signal, or common carotid intima-media thickness, between subjects with and without retinopathy were found. Conclusions: Type 1 diabetic patients, independently of their retinopathy status, show an increased angiogenesis of the VV of the common carotid artery compared with non-diabetic subjects. Diabetic microangiopathy, that according to our results would also affect the wall of the large arteries, could be a factor contributing to atherosclerosis in type 1 diabetes mellitus.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.atherosclerosis.2015.05.024
dc.relation.ispartofAtherosclerosis, 2015, vol. 241, num. 2, p. 334-338
dc.rights(c) Elsevier, 2015
dc.subject.classificationMalalties de la retina
dc.subject.classificationDiabetis
dc.subject.classificationAterosclerosi
dc.subject.otherRetinal diseases
dc.subject.otherDiabetes
dc.subject.otherAtherosclerosis
dc.titleMicroangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-09-15T11:56:50Z
dc.identifier.idgrec022804
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.1016/j.atherosclerosis.2015.05.024
dc.date.embargoEndDate10000-01-01


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