Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons
Fecha de publicación
2005Cita recomendada
Herrero Perpiñán, Enrique;
.
(2005)
.
Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons.
Revista Iberoamericana de Micología, 2005, vol. 22, p. 217-222.
https://doi.org/10.1016/S1130-1406(05)70046-2.
Metadatos
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The increasing number of fungal genomes whose sequence has been completed
permits their comparison both at the nucleotide and protein levels. The informa-
tion thus obtained improves our knowledge on evolutionary relationships betwe-
en fungi. Comparison of the Saccharomyces cerevisiae genome with other
Hemiascomycetes genomes confirms that a whole-genome duplication occurred
before the diversification between Candida glabrata and the Saccharomyces
sensu stricto species and after separation from the branch leading to the other
Hemiascomycetes. Duplication was followed by individual gene losses and re-
arrangements affecting extensive DNA regions. Although S. cerevisiae and
C. glabrata are two closely related yeast species at an evolutionary scale, their
different habitats and life styles correlate with specific gene differences and with
more extensive gene loses having occurred in the parasitic C. glabrata. At a clo-
ser evolutive scale, diversification among the sensu stricto species began with
nucleotide changes at the intergenic regions affecting sequences that are not
relevant for gene regulation, together with more extensive genome rearrange-
ments involving transposons and telomeric regions. One important characteristic
of fungal genomes that is shared with other eukaryotes is the fusion of gene
sequences coding for separate protein modules into a single open reading frame.
This allows diversification of protein functions while saving gene information.