Show simple item record

dc.contributor.authorSánchez Castro, Judit
dc.contributor.authorMarco Betés, Victor
dc.contributor.authorGómez Arbonés, Javier
dc.contributor.authorGarcía Cerecedo, Tomás
dc.contributor.authorLópez, Ricard
dc.contributor.authorTalavera, Elisabeth
dc.contributor.authorFernández-Ruiz, Sara
dc.contributor.authorAdemà, Vera
dc.contributor.authorMarugan, Isabel
dc.contributor.authorLuño, Elisa
dc.contributor.authorSanzo, Carmen
dc.contributor.authorVallespí, Teresa
dc.contributor.authorArenillas, Leonor
dc.contributor.authorMarco Buades, Josefa
dc.contributor.authorBatlle, Ana
dc.contributor.authorBuño, Ismael
dc.contributor.authorMartín Ramos, María Luisa
dc.contributor.authorBlázquez Rios, Beatriz
dc.contributor.authorCollado Nieto, Rosa
dc.contributor.authorVargas, María Teresa
dc.contributor.authorGonzález Martínez, Teresa
dc.contributor.authorSanz, Guillermo
dc.contributor.authorSolé, Francesc
dc.date.accessioned2015-07-16T12:11:47Z
dc.date.available2016-05-31T22:32:06Z
dc.date.issued2015-05-01
dc.identifier.issn1042-8194
dc.identifier.urihttp://hdl.handle.net/10459.1/48614
dc.description.abstractConventional G-banding cytogenetics (CC) detects chromosome 17 (chr17) abnormalities in 2% of patients with de novo myelodysplastic syndromes (MDS). We used CC and fluorescence in situ hybridization (FISH) (LSI p53/17p13.1) to assess deletion of 17p in 531 patients with de novo MDS from the Spanish Group of Hematological Cytogenetics. FISH detected<br>17 or 17p abnormalities in 13 cases (2.6%) in whom no 17p abnormalities were revealed by CC: 9% of patients with a normal karyotype, 0% in non-informative cytogenetics, 50% of patients with a chr17 abnormality without loss of 17p and in 4.7% of cases with an abnormal karyotype not involving chr17. Our results suggest that applying FISH of 17p13 to identify the number of copies of the TP53 gene could be beneficial in patients with a complex karyotype. We recommend using FISH of 17p13 in young patients with a normal karyotype or non-informative cytogenetics, and always in isolated del(17p)
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.3109/10428194.2015.1028053
dc.relation.ispartofLeukemia & Lymphoma, 2015
dc.rights(c) Informa Healthcare, 2015
dc.subjectMyelodysplastic syndromes
dc.subjectCytogenetics
dc.subjectFISH
dc.subjectChromosome 17
dc.titleFluorescence in situ hybridization (FISH) of TP53 for the detection of chromosome 17 abnormalities in myelodysplastic syndromes
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-07-16T12:11:47Z
dc.identifier.idgrec022759
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.3109/10428194.2015.1028053


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record