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dc.contributor.authorEstrada, Vicente
dc.contributor.authorGeijo, Paloma
dc.contributor.authorFuentes Ferrer, Manuel
dc.contributor.authorGarcía Alcalde, María Luisa
dc.contributor.authorRodrigo, María
dc.contributor.authorGalindo, María José
dc.contributor.authorMuñoz, Agustín
dc.contributor.authorDomingo, Pere
dc.contributor.authorRibera, Esteve
dc.contributor.authorCosín, Jaime
dc.contributor.authorViciana, Pompeyo
dc.contributor.authorLozano, Fernando
dc.contributor.authorTerrón, Alberto
dc.contributor.authorVergara, Antonio
dc.contributor.authorTeira, Ramón
dc.contributor.authorMuñoz Sánchez, Josefa
dc.contributor.authorRoca, Bernardino
dc.contributor.authorSánchez, Trinitario
dc.contributor.authorLópez Aldeguer, José
dc.contributor.authorDeig, Elisabeth
dc.contributor.authorVidal, Francisco
dc.contributor.authorPedrol, Enric
dc.contributor.authorCastaño Carracedo, Manuel
dc.contributor.authorPuig, Teresa
dc.contributor.authorGarrido, Myriam
dc.contributor.authorSuárez Lozano, Ignacio
dc.description.abstractBackground: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio.ca_ES
dc.publisherBioMed Centralca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofBMC Women’s Health, 2011, vol. 11, núm. 36, p. 1-8ca_ES
dc.rightscc-by, (c) Estrada et al., 2011ca_ES
dc.titleDyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohortca_ES

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