Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort

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2011
Author
Estrada, Vicente
Geijo, Paloma
Fuentes Ferrer, Manuel
García Alcalde, María Luisa
Rodrigo, María
Galindo, María José
Muñoz, Agustín
Domingo, Pere
Ribera, Esteve
Cosín, Jaime
Viciana, Pompeyo
Lozano, Fernando
Terrón, Alberto
Vergara, Antonio
Teira, Ramón
Muñoz Sánchez, Josefa
Roca, Bernardino
Sánchez, Trinitario
López Aldeguer, José
Deig, Elisabeth
Vidal, Francisco
Pedrol, Enric
Castaño Carracedo, Manuel
Puig, Teresa
Garrido, Myriam
Suárez Lozano, Ignacio
Suggested citation
Estrada, Vicente; Geijo, Paloma; Fuentes Ferrer, Manuel; García Alcalde, María Luisa; Rodrigo, María; Galindo, María José; ... Suárez Lozano, Ignacio. (2011) . Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort. BMC Women’s Health, 2011, vol. 11, núm. 36, p. 1-8. https://doi.org/10.1186/1472-6874-11-36.
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Abstract
Background: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio.
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http://hdl.handle.net/10459.1/48452
DOI
https://doi.org/10.1186/1472-6874-11-36
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BMC Women’s Health, 2011, vol. 11, núm. 36, p. 1-8
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