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dc.contributor.authorTorre Ruiz, M. A. de la
dc.contributor.authorTorres Rosell, Jordi
dc.contributor.authorAriño Carmona, Joaquín
dc.contributor.authorHerrero Perpiñán, Enrique
dc.date.accessioned2015-07-09T07:35:46Z
dc.date.issued2002
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/10459.1/48445
dc.description.abstractMaintenance of cellular integrity in Saccharomyces cerevisiae is carried out by the activation of the protein kinase C-mediated mitogen-activated protein kinase (PKC1-MAPK) pathway. Here we report that correct down-regulation of both basal and induced activity of the PKC1-MAPK pathway requires the SIT4 function. Sit4 is a protein phosphatase also required for a proper cell cycle progression. We present evidence demonstrat- ing that the G1 to S delay in the cell cycle, which occurs as a consequence of the absence of Sit4, is mediated by up-regulation of Pkc1 activity. Sit4 operates down- stream of the plasma membrane sensors Mid2, Wsc1, and Wsc2 and upstream of Pkc1. Sit4 affects all known bio- logical functions involving Pkc1, namely Mpk1 activity and cell wall integrity, actin cytoskeleton organization, and ribosomal gene transcription.ca_ES
dc.language.isoengca_ES
dc.publisherThe American Society for Biochemistry and Molecular Biologyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1074/jbc.M203515200ca_ES
dc.relation.ispartofThe Journal of Biological Chemistry, 2002, vol. 277, núm 36, p. 33468-33476ca_ES
dc.rights(c) The American Society for Biochemistry and Molecular Biology, 2002ca_ES
dc.titleSit4 is required for proper modulation of the biological functions mediated by Pkc1 and the cell integrity pathway in Saccharomyces cerevisiaeca_ES
dc.typearticleca_ES
dc.identifier.idgrec004203
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1074/jbc.M203515200


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