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dc.contributor.authorThuillier, Anne
dc.contributor.authorChibani, Kamel
dc.contributor.authorBellí i Martínez, Gemma
dc.contributor.authorHerrero Perpiñán, Enrique
dc.contributor.authorDumarçay, Stéphane
dc.contributor.authorGérardin, Philippe
dc.contributor.authorKohler, Annegret
dc.contributor.authorDeroy, Aurélie
dc.contributor.authorDhalleine, Tiphaine
dc.contributor.authorBchini, Raphael
dc.contributor.authorJacquot, Jean Pierre
dc.contributor.authorGelhaye, Eric
dc.contributor.authorMorel-Rouhier, Mélanie
dc.date.accessioned2015-07-07T11:14:06Z
dc.date.available2015-07-07T11:14:06Z
dc.date.issued2014
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10459.1/48422
dc.description.abstractThe first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of Phanerochaete chrysosporium genes was performed in presence of oak acetonic extracts. It reveals that in complement to the extracellular machinery of degradation, intracellular antioxidant and detoxification systems contribute to the lignolytic capabilities of fungi presumably by preventing cellular damages and maintaining fungal health. Focusing on these systems, a glutathione transferase (PcGTT2.1) has been selected for functional characterization. This enzyme, not characterized so far in basidiomycetes, has been first classified as a GTT2 in comparison to the Saccharomyces cerevisiae isoform. However, a deeper analysis shows that GTT2.1 isoform has functionally evolved to reduce lipid peroxidation by recognizing high-molecular weight peroxides as substrates. Moreover, the GTT2.1 gene has been lost in some non-wood decay fungi. This example suggests that the intracellular detoxification system could have evolved concomitantly with the extracellular ligninolytic machinery in relation to the capacity of fungi to degrade wood.ca_ES
dc.language.isoengca_ES
dc.publisherAmerican Society for Microbiologyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1128/AEM.02103-14ca_ES
dc.relation.ispartofApplied and Environmental Microbiology, 2014, vol. 80, núm. 20, p. 6316-6327ca_ES
dc.rights(c) American Society for Microbiology, 2014ca_ES
dc.subjecttranscriptomicsca_ES
dc.subjectPhanerochaete chrysosporiumca_ES
dc.subjectglutathione transferaseca_ES
dc.titleTranscriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase.ca_ES
dc.typearticleca_ES
dc.identifier.idgrec021778
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1128/AEM.02103-14


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