The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast

García-Martínez, José; Ayala, Guillermo; Pelechano, Vicent; Chávez, Sebastián; Herrero Perpiñán, Enrique; Pérez-Ortín, José E.

doi:https://doi.org/10.4161/trns.3.1.19416

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Issue date

2012

Author

García-Martínez, José

Ayala, Guillermo

Pelechano, Vicent

Chávez, Sebastián

Herrero Perpiñán, Enrique

Pérez-Ortín, José E.

Suggested citation

García-Martínez, José; Ayala, Guillermo; Pelechano, Vicent; Chávez, Sebastián; Herrero Perpiñán, Enrique; Pérez-Ortín, José E.; . (2012) . The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast. Transcription, 2012, vol. 3, núm. 1, p. 39-44. https://doi.org/10.4161/trns.3.1.19416.

Abstract

It has been recently stated that stress-responding genes in yeast are enriched in cryptic transcripts and that this is the cause of the differences observed between mRNA amount and RNA polymerase occupancy profiles. Other studies have shown that such differences are mainly due to modulation of mRNA

stabilities. Here we analyze the relationship between the presence of cryptic transcripts in genes and their stress response profiles. Despite some of the stress-responding gene groups being indeed enriched in specific classes of cryptic transcripts, we found no statistically significant evidence that cryptic transcription is responsible for the differences observed between mRNA and transcription rate profiles.

URI

http://hdl.handle.net/10459.1/48417

DOI

https://doi.org/10.4161/trns.3.1.19416

Is part of

Transcription, 2012, vol. 3, núm. 1, p. 39-44