Efficacy and tolerance of the topical application of potassium hydroxide (10% and 15%) in the treatment of molluscum contagiosum: Randomized clinical trial: Research protocol

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2011
Author
Marsal Mora, Josep Ramon
Cruz Esteve, María Inés
Teixidó Armengol, Conxita
Díez, Olga
Martínez, Mireia
Galindo Ortego, Gisela
Real, Jordi
Schoenenberger, Joan Antoni
Pera, Helena
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Marsal Mora, Josep Ramon; Cruz Esteve, María Inés; Teixidó Armengol, Conxita; Díez, Olga; Martínez, Mireia; Galindo Ortego, Gisela; ... Pera, Helena. (2011) . Efficacy and tolerance of the topical application of potassium hydroxide (10% and 15%) in the treatment of molluscum contagiosum: Randomized clinical trial: Research protocol. BMC Infectious Diseases, 2011, vol. 11, núm. 278, p. 1-6. https://doi.org/10.1186/1471-2334-11-278.
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Abstract
Background: Molluscum contagiosum is a non-severe pediatric viral infection. Because it is highly contagious and current treatments have negative aesthetic and psychological effects, we want to test an alternative treatment in the primary care setting, consisting of two different concentrations of
potassium hydroxide solution. Methods/design: The study design is a double-blind, randomized clinical trial, using three types of topical treatment. The treatment consist of daily applications of potassium hydroxide (KOH) in aqueous solution at 10% and 15% concentration, and a placebo administered in the control group. Four follow-up visits (at 15, 30, 45 and 60 days) are planned to evaluate treatment effectiveness and patient tolerance. The main outcome measure of the trial will be the healing rate, defined as lesion disappearance in the affected zones after the topic application of the experimental treatment. Secondary measures will be the principal characteristics and evolution of the affected zone (surface area, number of lesions, size and density of lesions), treatment tolerance (hyperpigmentation, itching, burning, pain), recurrence rate and the natural evolution of lesions in the control group. Discussion: KOH can potentially be an effective and safe treatment for MC in primary care, and can also reduce referrals to dermatologists and hospital pediatric departments. In addition, KOH may be a valid and less expensive alternative to current invasive treatments (surgical excision).
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http://hdl.handle.net/10459.1/48380
DOI
https://doi.org/10.1186/1471-2334-11-278
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BMC Infectious Diseases, 2011, vol. 11, núm. 278, p. 1-6
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Except where otherwise noted, this item's license is described as cc-by, (c) Marsal et al., 2011