Efficacy and tolerance of the topical application of potassium hydroxide (10% and 15%) in the treatment of molluscum contagiosum: Randomized clinical trial: Research protocol
Teixidó Armengol, Conxita
Galindo Ortego, Gisela
MetadataShow full item record
Background: Molluscum contagiosum is a non-severe pediatric viral infection. Because it is highly contagious and current treatments have negative aesthetic and psychological effects, we want to test an alternative treatment in the primary care setting, consisting of two different concentrations of potassium hydroxide solution. Methods/design: The study design is a double-blind, randomized clinical trial, using three types of topical treatment. The treatment consist of daily applications of potassium hydroxide (KOH) in aqueous solution at 10% and 15% concentration, and a placebo administered in the control group. Four follow-up visits (at 15, 30, 45 and 60 days) are planned to evaluate treatment effectiveness and patient tolerance. The main outcome measure of the trial will be the healing rate, defined as lesion disappearance in the affected zones after the topic application of the experimental treatment. Secondary measures will be the principal characteristics and evolution of the affected zone (surface area, number of lesions, size and density of lesions), treatment tolerance (hyperpigmentation, itching, burning, pain), recurrence rate and the natural evolution of lesions in the control group. Discussion: KOH can potentially be an effective and safe treatment for MC in primary care, and can also reduce referrals to dermatologists and hospital pediatric departments. In addition, KOH may be a valid and less expensive alternative to current invasive treatments (surgical excision).
Is part ofBMC Infectious Diseases, 2011, vol. 11, núm. 278, p. 1-6
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Evaluation of a family intervention programme for the treatment of overweight and obese children (Nereu Programme): a randomized clinical trial study protocol Serra Payà, Noemí; Ensenyat Solé, Assumpta; Real, Jordi; Castro Viñuales, Ivan; Zapata Rojas, Amalia; Galindo Ortego, Gisela; Solé Mir, Eduard; Bosch Muñoz, Jordi; Mur, José María; Teixidó Armengol, Conxita (BioMed Central, 2013)Background: Obesity is mainly attributed to environmental factors. In developed countries, the time spent on physical activity tasks is decreasing, whereas sedentary behaviour patterns are increasing. The purpose of the ...
Effectiveness of a Multi-Component Intervention for Overweight and Obese Children (Nereu Program): A Randomized Controlled Trial Serra Payà, Noemí; Castro Viñuales, Ivan; Real, Jordi; Sinfreu Bergués, Xènia; Zapata Rojas, Amalia; Galindo Ortego, Gisela; Solé Mir, Eduard; Mur, José María; Ensenyat Solé, Assumpta; Teixidó Armengol, Conxita (Public Library of Science, 2015)Introduction: Treatment of childhood obesity is a complex challenge for primary health care professionals. Objectives: To evaluate the effectiveness of the Nereu Program in improving anthropometric parameters, physical ...
Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial Pons Rodríguez, Anna; Forné Izquierdo, Carles; Vilaplana Mayoral, Jordi; Cruz Esteve, María Inés; Sánchez-López, Isabel; Reñé Reñé, Mercè; Cazorla, Cristina; Hernández Andreu, Marta; Galindo Ortego, Gisela; Llorens Gabandé, Montserrat; Laza-Vásquez, Celmira; Balaguer Llaquet, Pau; Martínez Alonso, Montserrat; Rué i Monné, Montserrat (BMJ Publishing Group, 2020-12-23)Introduction Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of ...