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dc.contributor.authorVlierberghe, Pieter Van
dc.contributor.authorAmbesi-Impiombato, Alberto
dc.contributor.authorPérez-García, Arianne
dc.contributor.authorHaydu, J. Erika
dc.contributor.authorRigo, Isaura
dc.contributor.authorHadler, Michael
dc.contributor.authorTosello, Valeria
dc.contributor.authorDella Gatta, Giusy
dc.contributor.authorPaietta, Elisabeth
dc.contributor.authorRacevskis, Janis
dc.contributor.authorWiernik, Peter H.
dc.contributor.authorLuger, Selina M.
dc.contributor.authorRowe, Jacob M.
dc.contributor.authorRué i Monné, Montserrat
dc.contributor.authorFerrando, Adolfo A.
dc.description.abstractEarly immature T cell acute lymphoblastic leukemias (T-ALLs) account for 5–10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. Many adult immature T-ALLs harbored mutations in myeloid-specific oncogenes and tumor suppressors including IDH1, IDH2, DNMT3A, FLT3, and NRAS. Moreover, we identified ETV6 mutations as a novel genetic lesion uniquely present in immature adult T-ALL. Our results demonstrate that early immature adult T-ALL represents a heterogeneous category of leukemias characterized by the presence of overlapping myeloid and T-ALL characteristics, and highlight the potential role of ETV6 mutations in these tumors.ca_ES
dc.publisherThe Rockefeller University Pressca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofThe Journal of Experimental Medicine, 2011, vol. 208, núm. 13, p. 2571-2579ca_ES
dc.rightscc-by-nc-sa, (c) Vlierberghe et al., 2011ca_ES
dc.titleETV6 mutations in early immature human T cell leukemiasca_ES

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cc-by-nc-sa, (c) Vlierberghe et al., 2011
Except where otherwise noted, this item's license is described as cc-by-nc-sa, (c) Vlierberghe et al., 2011