ETV6 mutations in early immature human T cell leukemias

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2011
Author
Vlierberghe, Pieter Van
Ambesi-Impiombato, Alberto
Pérez-García, Arianne
Haydu, J. Erika
Rigo, Isaura
Hadler, Michael
Tosello, Valeria
Della Gatta, Giusy
Paietta, Elisabeth
Racevskis, Janis
Wiernik, Peter H.
Luger, Selina M.
Rowe, Jacob M.
Rué i Monné, Montserrat
Ferrando, Adolfo A.
Suggested citation
Vlierberghe, Pieter Van; Ambesi-Impiombato, Alberto; Pérez-García, Arianne; Haydu, J. Erika; Rigo, Isaura; Hadler, Michael; ... Ferrando, Adolfo A.. (2011) . ETV6 mutations in early immature human T cell leukemias. The Journal of Experimental Medicine, 2011, vol. 208, núm. 13, p. 2571-2579. https://doi.org/10.1084/jem.20112239.
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Abstract
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for 5–10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures
in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. Many adult immature T-ALLs harbored mutations in myeloid-specific oncogenes and tumor suppressors including IDH1, IDH2, DNMT3A, FLT3, and NRAS. Moreover, we identified ETV6 mutations as a novel genetic lesion uniquely present in immature adult T-ALL. Our results demonstrate that early immature adult T-ALL represents a heterogeneous category of leukemias characterized by the presence of overlapping myeloid and T-ALL characteristics, and highlight the potential role of ETV6 mutations in these tumors.
URI
http://hdl.handle.net/10459.1/48320
DOI
https://doi.org/10.1084/jem.20112239
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The Journal of Experimental Medicine, 2011, vol. 208, núm. 13, p. 2571-2579
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cc-by-nc-sa, (c) Vlierberghe et al., 2011
Except where otherwise noted, this item's license is described as cc-by-nc-sa, (c) Vlierberghe et al., 2011