ETV6 mutations in early immature human T cell leukemias

Thumbnail
View/Open
Issue date
2011
Author
Vlierberghe, Pieter Van
Ambesi-Impiombato, Alberto
Pérez-García, Arianne
Haydu, J. Erika
Rigo, Isaura
Hadler, Michael
Tosello, Valeria
Della Gatta, Giusy
Paietta, Elisabeth
Racevskis, Janis
Wiernik, Peter H.
Luger, Selina M.
Rowe, Jacob M.
Rué i Monné, Montserrat
Ferrando, Adolfo A.
Suggested citation
Vlierberghe, Pieter Van; Ambesi-Impiombato, Alberto; Pérez-García, Arianne; Haydu, J. Erika; Rigo, Isaura; Hadler, Michael; ... Ferrando, Adolfo A.. (2011) . ETV6 mutations in early immature human T cell leukemias. The Journal of Experimental Medicine, 2011, vol. 208, núm. 13, p. 2571-2579. https://doi.org/10.1084/jem.20112239.
Impact

Google Scholar logo  Google Scholar
Share
Export to Mendeley
Metadata
Show full item record
Abstract
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for 5–10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. Many adult immature T-ALLs harbored mutations in myeloid-specific oncogenes and tumor suppressors including IDH1, IDH2, DNMT3A, FLT3, and NRAS. Moreover, we identified ETV6 mutations as a novel genetic lesion uniquely present in immature adult T-ALL. Our results demonstrate that early immature adult T-ALL represents a heterogeneous category of leukemias characterized by the presence of overlapping myeloid and T-ALL characteristics, and highlight the potential role of ETV6 mutations in these tumors.
URI
http://hdl.handle.net/10459.1/48320
DOI
https://doi.org/10.1084/jem.20112239
Is part of
The Journal of Experimental Medicine, 2011, vol. 208, núm. 13, p. 2571-2579
Collections

The following license files are associated with this item:

cc-by-nc-sa, (c) Vlierberghe et al., 2011
Except where otherwise noted, this item's license is described as cc-by-nc-sa, (c) Vlierberghe et al., 2011