Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009–2010

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2012
Author
González-Candelas, Fernando
Astray, Jenaro
Alonso, Jordi
Castro, Ady
Cantón, Rafael
Galán, Juan Carlos
Garín, Olatz
Sáez, Marc
Soldevila, Núria
Baricot, Maretva
Castilla, Jesús
Godoy i García, Pere
Delgado-Rodríguez, Miguel
Martín, Vicente
Mayoral, José María
Pumarola, Tomás
Quintana, José María
Tamames, Sonia
Domínguez García, Àngela
CIBERESP Cases and Controls in Pandemic Influenza Working Group
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González-Candelas, Fernando; Astray, Jenaro; Alonso, Jordi; Castro, Ady; Cantón, Rafael; Galán, Juan Carlos; ... CIBERESP Cases and Controls in Pandemic Influenza Working Group. (2012) . Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009–2010. PLoS One, 2012, vol. 7, núm. 3, e33139. https://doi.org/10.1371/journal.pone.0033139.
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Abstract
The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI$40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population.
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http://hdl.handle.net/10459.1/48241
DOI
https://doi.org/10.1371/journal.pone.0033139
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PLoS One, 2012, vol. 7, núm. 3, e33139
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cc-by, (c) González-Candelas et al., 2012
Except where otherwise noted, this item's license is described as cc-by, (c) González-Candelas et al., 2012