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dc.contributor.authorRibas i Fortuny, Judit
dc.contributor.authorGómez Arbonés, Javier
dc.contributor.authorBoix Torras, Jacint
dc.date.accessioned2015-03-26T18:10:38Z
dc.date.available2015-03-26T18:10:38Z
dc.date.issued2005
dc.identifier.issn0014-2999
dc.identifier.urihttp://hdl.handle.net/10459.1/48115
dc.description.abstractOlomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the involvement of an extrinsic pathway [Ribas, J., Boix, J., 2004. Cell differentiation, Caspase inhibition, and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp. Cell Res. 295 9<br>24.], which depends on either Caspase 8 or Caspase 10 activation. However, neither Caspase 8 nor Caspase 10 is expressed in SH- SY5Y cells because of gene silencing. Upon Olomoucine or Roscovitine treatment, no re-expression of Caspase 8 or Caspase 10 was found. Therefore, in SH-SY5Y cells, this type of drugs is not triggering a canonical, Caspase 8/10-mediated, extrinsic apoptotic pathway. © 2005 Elsevier B.V. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.ejphar.2005.09.021
dc.relation.ispartofEuropean Journal of Pharmacology, 2005, vol. 524, num. 1-3, p. 49-52
dc.rights(c) Elsevier, 2005
dc.subjectApoptosis
dc.subjectCell Cycle
dc.subjectCaspases
dc.subjectRoscovitine
dc.subjectOlomoucine
dc.subject.classificationApoptosi
dc.subject.classificationCicle cel·lular
dc.subject.otherApoptosis
dc.subject.otherCell cycle
dc.titleCaspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-03-26T18:10:38Z
dc.identifier.idgrec007155
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2005.09.021


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