Study of the catabolism of thyme phenols combining in-vitro fermentation and human intervention.

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2014
Author
Mosele, Juana
Martín Peláez, Sandra María
Macià i Puig, Ma Alba
Farràs, Marta
Valls, Rosa M.
Catalán Santos, Úrsula
Motilva Casado, Mª José
Suggested citation
Mosele, Juana; Martín Peláez, Sandra María; Macià i Puig, Ma Alba; Farràs, Marta; Valls, Rosa M.; Catalán Santos, Úrsula; Motilva Casado, Mª José; . (2014) . Study of the catabolism of thyme phenols combining in-vitro fermentation and human intervention.. Journal of Agricultural and Food Chemistry, 2014, vol. 62, p. 10954-10961. https://doi.org/10.1021/jf503748y.
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Abstract
The gut metabolism of four thyme phenolics (monoterpenes thymol and carvacrol, rosmarinic acid, and eriodictyol) was evaluated in vitro. After the in vitro transformations of the individual phenols had been studied, the presence of their microbial metabolites was investigated in human feces collected before and after a sustained intake (3 weeks) of 25 mL/day of a thyme phenol-enriched olive oil. Results of in vitro fermentation showed low degradation of thymol and carvacrol. By contrast, large catabolism was noted when rosmarinic acid and eriodictyol were fermented, yielding hydroxyphenylpropionic acid as the main metabolite. In accordance with these results, after the in vivo intervention with thyme phenol-enriched olive oil, an increase in the concentration of hydroxyphenylpropionic and phenylpropionic acids was observed in human feces, confirming the effective in vivo microbial degradation of rosmarinic acid and eriodictyol. Carvacrol was detected in fecal samples at trace levels, suggesting that monoterpenes are well absorbed in the upper part of the gastrointestinal tract.
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http://hdl.handle.net/10459.1/48107
DOI
https://doi.org/10.1021/jf503748y
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Journal of Agricultural and Food Chemistry, 2014, vol. 62, p. 10954-10961
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