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dc.contributor.authorBilbao, Ainhoa
dc.contributor.authorBlanco Calvo, Eduardo
dc.contributor.authorLuque-Rojas, María Jesús
dc.contributor.authorSuárez, Juan
dc.contributor.authorPalomino, Ana
dc.contributor.authorVida, Margarita
dc.contributor.authorAraos, Pedro
dc.contributor.authorBermúdez-Silva, Francisco J.
dc.contributor.authorFernández Espejo, Emilio
dc.contributor.authorSpanagel, Rainer
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.date.accessioned2015-02-13T14:35:12Z
dc.date.issued2013-01-00
dc.identifier.issn1355-6215
dc.identifier.urihttp://hdl.handle.net/10459.1/47964
dc.description.abstractOleoylethanolamide (OEA) is an acylethanolamide that acts as an agonist of nuclear peroxisome proliferator-activated receptor alpha (PPARa) to exert their biological functions, which include the regulation of appetite and metabolism. Increasing evidence also suggests that OEA may participate in the control of reward-related behaviours. However, direct experimental evidence for the role of the OEA-PPARa receptor interaction in drug-mediated behaviours, such as cocaine-induced behavioural phenotypes, is lacking. The present study explored the role of OEA and its receptor PPARa on the psychomotor and rewarding responsiveness to cocaine using behavioural tests indicative of core components of addiction. We found that acute administration of OEA (1, 5 or 20?mg/kg, i.p.) reduced spontaneous locomotor activity and attenuated psychomotor activation induced by cocaine (20?mg/kg) in C57Bl/6 mice. However, PPARa receptor knockout mice showed normal sensitization, although OEA was capable of reducing behavioural sensitization with fewer efficacies. Furthermore, conditioned place preference and reinstatement to cocaine were intact in these mice. Our results indicate that PPARa receptor does not play a critical, if any, role in mediating short- and long-term psychomotor and rewarding responsiveness to cocaine. However, further research is needed for the identification of the targets of OEA for its inhibitory action on cocaine-mediated responses.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.isformatofReproducció del document publicat a : https://doi.org/10.1111/adb.12006
dc.relation.ispartofAddiction Biology, 2013, vol. 18, núm. 1, p. 78-87
dc.rights(c)The Authors, John Wiley & Sons, 2013
dc.subjectCocaine
dc.subjectKnockout
dc.subjectMotor sensitization
dc.subjectOleoylethanolamide
dc.subjectPPARa
dc.subject.classificationCocaïna
dc.subject.otherCocaine
dc.titleOleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARa receptor-independent mechanism
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-02-13T14:35:13Z
dc.identifier.idgrec020238
dc.type.versionpublishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.1111/adb.12006
dc.date.embargoEndDate10000-01-01


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