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dc.contributor.authorCastilla Ortega, Estela
dc.contributor.authorRosell del Valle, Cristina
dc.contributor.authorBlanco Calvo, Eduardo
dc.contributor.authorPedraza Benitez, Carmen
dc.contributor.authorChun, Jerold
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorEstivill Torrús, Guillermo
dc.contributor.authorSantín Núñez, Luis Javier
dc.date.accessioned2015-02-13T14:11:16Z
dc.date.issued2013-09-19
dc.identifier.issn0168-0102
dc.identifier.urihttp://hdl.handle.net/10459.1/47963
dc.description.abstractThis work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of free wheel running and were tested for open-field behavior and adult hippocampal neurogenesis (cell proliferation, immature neurons, cell survival). Running decreased anxiety-like behavior in both genotypes but increased exploration only in the normal mice. While running affected all neurogenesis-related measures in normal mice (especially in the suprapyramidal blade of the dentate gyrus), only a moderate increase in cell survival was found in the mutants. Importantly, the LPA1-nulls showed notably reduced running. Analysis suggested that defective running in the LPA1-null mice could contribute to explain the scarce benefit of the voluntary exercise treatment. On the other hand, a literature review revealed that voluntary exercise is frequently used to modulate behavior and the hippocampus in transgenic mice, but half of the studies did not assess the quantity of running, overlooking any potential running impairments. This study adds evidence to the relevance of the quantity of exercise performed, emphasizing the importance of its assessment in transgenic mice research.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.neures.2013.09.004
dc.relation.ispartofNeuroscience Research, 2013, vol. 77, núm. 3, p. 170-179
dc.rights(c) Elsevier, 2013
dc.subjectAdult hippocampal neurogenesis
dc.subjectDentate gyrus’ suprapyramidal and infrapyramidal blades
dc.subjectEnvironmental enrichment
dc.subjectLysophosphatidic acid
dc.subjectPrincipal components factorial analysis
dc.subject.classificationNeurobiologia
dc.subject.otherNeurobiology
dc.titleReduced wheel running and blunted effects of voluntary exercise in LPA1-null mice: the importance of assessing the amount of running in transgenic mice studies
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-02-13T14:11:16Z
dc.identifier.idgrec020237
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.1016/j.neures.2013.09.004
dc.date.embargoEndDate2025-01-01


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