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dc.contributor.authorHerrera, María Inés
dc.contributor.authorRomero, Juan Ignacio
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorBlanco Calvo, Eduardo
dc.contributor.authorCapani, Francisco
dc.date.accessioned2015-02-13T08:53:51Z
dc.date.issued2014-10-18
dc.identifier.issn2409-3564
dc.identifier.urihttp://hdl.handle.net/10459.1/47962
dc.description.abstractPerinatal asphyxia (PA) is still a serious health problem associated with neuronal loss and morbidity. PA pathophysiology implies oxidative stress, cell damage and over activation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. Oleoylethanolamide (OEA), a cannabinoid agonist that exerts anti-inflammatory actions through PPARα activation, could be a possible target for neuroprotection. However, its role in perinatal hypoxic brain injury remains still unknown. In this study, we evaluated the behavioral consequences of OEA treatment in 30 days-old asphyctic rats. Results indicated that rats subjected to OEA administration showed an improvement in exploratory locomotion. This data suggests a possible neuroprotective role of OEA in severe perinatal asphyxia modifications.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherCosmos Scholars Publishing House
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.15379/2409-3564.2014.01.01.3
dc.relation.ispartofJournal of advanced neuroscience research, 2014, vol. 1, p. 22-26
dc.rights(c) Cosmos Scholars Publishing House, 2014
dc.subjectNeuroprotection
dc.subjectAnti-inflammatory effect
dc.subjectExploratory locomotion
dc.subjectPerinatal asphyxia
dc.subject.classificationAgents antiinflamatoris
dc.subject.classificationAparell locomotor
dc.subject.classificationAsfíxia neonatal
dc.titleBehavioral Effect of Oleoylethanolamide on Perinatal Asphyxia
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-02-13T08:53:52Z
dc.identifier.idgrec021998
dc.type.versionpublishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.15379/2409-3564.2014.01.01.3


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