Show simple item record

dc.contributor.authorOrio, Laura
dc.contributor.authorPavón, Francisco Javier
dc.contributor.authorBlanco Calvo, Eduardo
dc.contributor.authorSerrano, Antonia
dc.contributor.authorAraos, Pedro
dc.contributor.authorPedraz, María
dc.contributor.authorRivera, Patricia
dc.contributor.authorCalado, Montserrat
dc.contributor.authorSuárez, Juan
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.date.accessioned2015-01-23T09:32:26Z
dc.date.issued2013
dc.identifier.issn1381-6128
dc.identifier.urihttp://hdl.handle.net/10459.1/47731
dc.description.abstractThis review analyzes the roles of lipid transmitters, especially those derived from the cleavage of membrane phospholipids, in cocaine-associated behaviors. These lipid signals are important modulators of information processing in the brain, affecting transmitter release, neural plasticity, synaptogenesis, neurogenesis, and cellular energetics. This broad range of actions makes them suitable targets for pharmaceutical development of cocaine addiction therapies because they participate in the main cellular processes underlying the neuroadaptations associated with chronic use of this psychostimulant. The main lipid transmitters reviewed here include a) acylethanolamides and acylglycerols acting on cannabinoid receptors, such as anandamide and 2-arachidonoylglycerol; b) acylethanolamides that do not act on cannabinoid receptors, such as oleoylethanolamide; c) eicosanoids derived from arachidonic acid, including prostaglandins; and d) lysophosphatidic acid, focusing on the role of its LPA-1 receptor. Direct experimental evidence for the significance of these lipids in cocaine-related behaviors is presented and discussed. Additionally, the roles for both their biosynthesis and degradation pathways, as well as the participation of their receptors, are examined. Overall, lipid transmitter signaling can offer new targets for the development of therapies for cocaine addiction.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.2174/138161281940131209143421
dc.relation.ispartofCurrent Pharmaceutical Design, 2013, vol. 19, num. 40, p. 7036-7049
dc.rights(c) Bentham Science Publishers, 2013
dc.subjectOleoylethanolamide
dc.subjectPPAR alpha
dc.subjectKnockout
dc.subjectCocaine
dc.subjectMotor sensitization
dc.subject.classificationCocaïna
dc.subject.otherCocaine
dc.titleLipid Transmitter Signaling as a New Target for Treatment of Cocaine Addiction: New Roles for Acylethanolamides and Lysophosphatidic Acid
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2015-01-23T09:32:27Z
dc.identifier.idgrec020240
dc.type.versionpublishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doihttps://doi.org/10.2174/138161281940131209143421
dc.date.embargoEndDate10000-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record