L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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Envíos recientes

  • Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial 

    Pons Rodríguez, Anna; Forné, Carles; Vilaplana Mayoral, Jordi; Cruz Esteve, María Inés; Sánchez-López, Isabel; Reñé Reñé, Mercè; Cazorla, Cristina; Hernández Andreu, Marta; Galindo Ortego, Gisela; Llorens Gabandé, Montserrat; Laza-Vásquez, Celmira; Balaguer Llaquet, Pau; Martínez Alonso, Montserrat; Rué i Monné, Montserrat (BMJ Publishing Group, 2020-12-23)
    Introduction Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of ...
  • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

    Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
    Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...
  • Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury 

    Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Tarabal Mostazo, Olga; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley, 2021-01-02)
    Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ...
  • Succination of protein thiols in human brain aging 

    Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natalia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
    Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
  • Pleural diseases and COVID-19: ubi fumus, ibi ignis 

    Porcel Pérez, José Manuel (European Respiratory Society, 2020)
  • Machine learning techniques for mortality prediction in critical traumatic patients: anatomic and physiologic variables from the RETRAUCI study 

    Servià Goixart, Lluís; Montserrat, Neus; Badia Castello, Mariona; Llompart-Pou, Juan Antonio; Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Sánchez-Casado, Marcelino; Jiménez, José Manuel; Mayor, Dolores María; Trujillano Cabello, Javier (BMC, 2020-10-20)
    Interest in models for calculating the risk of death in traumatic patients admitted to ICUs remains high. These models use variables derived from the deviation of physiological parameters and/or the severity of anatomical ...
  • Interactions of GMP with human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 converge in the regulation of the Gcn2 pathway 

    Mechoud, Mónica A.; Pujol Carrión, Núria; Montellá-Manuel, Sandra; Torre Ruiz, M. A. de la (American Society for Microbiology, 2020-07-02)
    The human monothiol glutaredoxin Glrx3 (PICOT) is ubiquitously distributed in cytoplasm and nuclei in mammalian cells. Its overexpression has been associated with the development of several types of tumors, whereas its ...
  • Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart 

    Park, Min; Nishimura, Takanori; Baeza-Garza, Carlos D.; Caldwell, Stuart T.; Boon Li Pun, Pamela; Prag, Hiran A.; Young, Tim; Sauchanka, Olga; Logan, Angela; Forkink, Marleen; Gruszczyk, Anja V.; Prime, Tracy A.; Arndt, Sabine; Naudí i Farré, Alba; Pamplona Gras, Reinald; Coughlan, Melinda T.; Tate, Mitchel; Ritchie, Rebecca H.; Caicci, Federico; Kaludercic, Nina; Lisa, Fabio Di; Smith, Robin A. J.; Hartley, Richard C.; Murphy, Michael P.; Krieg,Thomas (Springer, 2020-12-01)
    Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used ...
  • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

    Jové Font, Mariona; Mota Martorell, Natalia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
    The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
  • Effectiveness of workplace exercise interventions in the treatment of musculoskeletal disorders in office workers: a protocol of a systematic review 

    Tersa Miralles, Carlos; Pastells Peiró, Roland; Rubí Carnacea, Francesc; Bellon, Filip; Rubinat, Esther (BMJ Publishing Group, 2020-11-23)
    Introduction Physical inactivity due to changes in our society towards more sedentary behaviours is leading to health problems. Increasing physical activity might be a good strategy to improve physical strength and reduce ...
  • The lipidome fingerprint of longevity 

    Jové Font, Mariona; Mota Martorell, Natalia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
    Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...
  • Alterations in one-carbon metabolism in celiac disease 

    Martin-Masot, Rafael; Mota Martorell, Natalia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
    Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
  • Poor sleep quality experience and self-management strategies in fibromyalgia: a qualitative metasynthesis 

    Climent Sanz, Carolina; Morera-Amenós, Genís; Bellon, Filip; Pastells Peiró, Roland; Blanco Blanco, Joan; Valenzuela Pascual, Francesc; Gea Sánchez, Montserrat (MDPI, 2020-12-10)
    Poor sleep quality is a major concern and a highly prevalent symptom in fibromyalgia. We aimed to develop a metasynthesis of qualitative studies to assess how people diagnosed with fibromyalgia experience and manage poor ...
  • Neuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseases 

    Gallart-Palau, Xavier; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Sábado, Javier; Correa, Francisco; Cerveró Cebrià, Clàudia; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (2014)
    Pioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display ...
  • Mitochondrial localization of the yeast forkhead factor Hcm1 

    Rodríguez Colman, Maria José; Ros Salvador, Joaquim; Cabiscol Català, Elisa (MDPI, 2020-12)
    Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and ...
  • WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion 

    Rodriguez-Hernandez, Irene; Maiques Carlos, Oscar; Kohlhammer, Leonie; Cantelli, Gaia; Perdrix-Rosell, Anna; Monger, Joanne; Fanshawe, Bruce; Bridgeman, Victoria L.; Karagiannis, Sophia N.; Penin, Rosa M.; Marcolval, Joaquim; Martí Laborda, Rosa Ma.; Matias-Guiu, Xavier; Fruhwirth, Gilbert O.; Orgaz, Jose L.; Malanchi, Ilaria; Sanz Moreno, Victoria (Nature Research, 2020)
    Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels ...
  • Evaluación del grado de adherencia a las recomendaciones nutricionales en el paciente crítico 

    Servià Goixart, Lluís; López Delgado, Juan Carlos; Grau Carmona, Teodoro (Aran Ediciones, 2019-06-01)
    Objetivo: la aplicación del soporte nutricional especializado (SNE) es difícil a nivel organizativo debido a la complejidad de las guías de práctica clínica y desconocemos el grado de adherencia a las recomendaciones ...
  • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

    Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
    Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
  • Economic evaluations of screening strategies for the early detection of colorectal cancer in the average-risk population: a systematic literature review 

    Mendivil, Joan; Appierto, Marilena; Aceituno, Susana; Comas, Mercè; Rué i Monné, Montserrat (Public Library of Science, 2019-12-31)
    Background Colorectal cancer (CRC) screening has proven effective in reducing CRC mortality. This study aimed to systematically review, and evaluate the reporting quality, of the economic evidence regarding CRC screening ...
  • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

    Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (Public Library of Science, 2020)
    Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...

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