L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • The lipidome fingerprint of longevity 

    Jové Font, Mariona; Mota Martorell, Natalia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
    Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...
  • Alterations in one-carbon metabolism in celiac disease 

    Martin-Masot, Rafael; Mota Martorell, Natalia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
    Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
  • Poor sleep quality experience and self-management strategies in fibromyalgia: a qualitative metasynthesis 

    Climent Sanz, Carolina; Morera-Amenós, Genís; Bellon, Filip; Pastells Peiró, Roland; Blanco Blanco, Joan; Valenzuela Pascual, Francesc; Gea Sánchez, Montserrat (MDPI, 2020-12-10)
    Poor sleep quality is a major concern and a highly prevalent symptom in fibromyalgia. We aimed to develop a metasynthesis of qualitative studies to assess how people diagnosed with fibromyalgia experience and manage poor ...
  • Neuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseases 

    Gallart-Palau, Xavier; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Sábado, Javier; Correa, Francisco; Cerveró Cebrià, Clàudia; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (2014)
    Pioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display ...
  • Mitochondrial localization of the yeast forkhead factor Hcm1 

    Rodríguez Colman, Maria José; Ros Salvador, Joaquim; Cabiscol Català, Elisa (MDPI, 2020-12)
    Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and ...
  • WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion 

    Rodriguez-Hernandez, Irene; Maiques Carlos, Oscar; Kohlhammer, Leonie; Cantelli, Gaia; Perdrix-Rosell, Anna; Monger, Joanne; Fanshawe, Bruce; Bridgeman, Victoria L.; Karagiannis, Sophia N.; Penin, Rosa M.; Marcolval, Joaquim; Martí Laborda, Rosa Ma.; Matias-Guiu, Xavier; Fruhwirth, Gilbert O.; Orgaz, Jose L.; Malanchi, Ilaria; Sanz Moreno, Victoria (Nature Research, 2020)
    Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels ...
  • Evaluación del grado de adherencia a las recomendaciones nutricionales en el paciente crítico 

    Servià Goixart, Lluís; López Delgado, Juan Carlos; Grau Carmona, Teodoro (Aran Ediciones, 2019-06-01)
    Objetivo: la aplicación del soporte nutricional especializado (SNE) es difícil a nivel organizativo debido a la complejidad de las guías de práctica clínica y desconocemos el grado de adherencia a las recomendaciones ...
  • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

    Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
    Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
  • Economic evaluations of screening strategies for the early detection of colorectal cancer in the average-risk population: a systematic literature review 

    Mendivil, Joan; Appierto, Marilena; Aceituno, Susana; Comas, Mercè; Rué i Monné, Montserrat (Public Library of Science, 2019-12-31)
    Background Colorectal cancer (CRC) screening has proven effective in reducing CRC mortality. This study aimed to systematically review, and evaluate the reporting quality, of the economic evidence regarding CRC screening ...
  • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

    Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (Public Library of Science, 2020)
    Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
  • Could IL-17A be a novel therapeutic target in diabetic nephropathy? 

    Lavoz, Carolina; Rayego Mateos, Sandra; Orejudo, Macarena; Opazo Rios, Lucas; Marchant, Vanessa; Marquez Exposito, Laura; Tejera Muñoz, Antonio; Navarro González, Juan F.; Droguett, Alejandra; Ortiz, Alberto; Egido, Jesús; Mezzano, Sergio; Rodrigues-Diez, Raul; Ruiz-Ortega, Marta (MDPI, 2020)
    Chronic kidney disease has become a major medical issue in recent years due to its high prevalence worldwide, its association with premature mortality, and its social and economic implications. A number of patients gradually ...
  • Usefulness of clinical definitions of influenza for public health surveillance purposes 

    Domínguez, Ángela; Soldevila, Núria; Torner, Núria; Martínez, Ana; Godoy i García, Pere; Rius, Cristina; Jané, Mireia (MDPI, 2020)
    This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of ...
  • Meningococcal disease and vaccines: still many questions and some answers 

    Godoy i García, Pere; Castilla, Jesús; Astray, Jenaro; Tuells, José; Barrabeig, Irene; Domínguez, Ángela (Sociedad Española de Salud Pública y Administración Sanitaria, 2020)
  • PVT1 long non-coding RNA in gastrointestinal cancer 

    Martínez Barriocanal, Águeda; Arango, Diego; Dopeso, Higinio (Frontiers Media, 2020)
    Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the ...
  • Special Issue "Diabetic Nephropathy: Diagnosis, Prevention and Treatment" 

    Ruiz Ortega, Marta; Rodrigues-Diez, Raul; Lavoz, Carolina; Rayego Mateos, Sandra (MDPI, 2020)
    Diabetic nephropathy (DN) is the main cause of end-stage renal disease. DN is a complex disease mediated by genetic and environmental factors, and many cellular and molecular mechanisms are involved in renal damage in ...
  • Comprehensive constitutional genetic and epigenetic characterization of lynch-like individuals 

    Damaso, Estela; Gonzalez Acosta, Maribel; Vargas Parra, Gardenia; Navarro, Matilde; Balmana, Judith; Ramon y Cajal, Teresa; Tuset, Noemi; Thompson, Bryony A.; Marín, Fàtima; Fernández, Anna; Gómez, Carolina; Velasco, Àngela; Solanes, Ares; Iglesias, Sílvia; Urgel, Gisela; López, Consol; del Valle, Jesús; Campos, Olga; Santacana, Maria; Matias-Guiu, Xavier; Lázaro, Conxi; Valle, Laura; Brunet, Joan; Pineda, Marta; Capella, Gabriel (MDPI, 2020)
    The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive ...
  • Determinants of sensitivity to radiotherapy in endometrial cancer 

    Sorolla Bardají, Maria Alba; Parisi Capdevila, Eva; Sorolla Bardají, Anabel (MDPI, 2020)
    Radiotherapy is one of the cornerstone treatments for endometrial cancer and has successfully diminished the risk of local recurrences after surgery. However, a considerable percentage of patients suffers tumor relapse due ...
  • From seabed to bedside: a review on promising marine anticancer compounds 

    Wang, Edina; Sorolla Bardají, Maria Alba; Gopal Krishnan, Priya Darshini; Sorolla, Anabel (MDPI, 2020)
    The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. ...
  • IL-17A as a potential therapeutic target for patients on peritoneal dialysis 

    Marchant, Vanessa; Tejera Muñoz, Antonio; Marquez Exposito, Laura; Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Tejedor, Lucia; Santos Sanchez, Laura; Egido, Jesús; Valdivielso Revilla, José Manuel; Fraser, Donald J.; López Cabrera, Manuel; Selgas, Rafael; Ruiz-Ortega, Marta (MDPI, 2020)
    Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy ...
  • Fluid Intake Recommendation Considering the Physiological Adaptations of Adults Over 65 Years: A Critical Review 

    Masot, Olga; Miranda Iglesias, Jessica; Lavedán, Ana; Paraiso Pueyo, Elena; Pascual, Alexandra; Botigué, Teresa (MDPI, 2020-11-04)
    The aim of this critical review was to clarify recommended fluid intake for older people. A literature search of published articles and guidelines on fluid intake recommendations until April 2020 was carried out using ...

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