Now showing items 1-20 of 1137

    • 1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter 

      Cardús i Figueras, Anna; Panizo García, Sara; Encinas Martín, Mario; Dolcet Roca, Xavier; Gallego, Carme; Aldea, Martí; Fernandez, Elvira; Valdivielso Revilla, José Manuel (Elsevier, 2009)
      In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)2D3) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro. However, ...
    • 2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53 

      Mattiolo, Paolo; Barbero-Farran A.; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2014)
      2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ...
    • 2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels 

      Yeramian Hakim, Andree; Veà Jódar, Àlvar; Benítez, Sandra; Ribera i Calvet, Joan; Domingo, Mónica; Santacana Espasa, Maria; Martínez Alonso, Montserrat; Maiques Carlos, Oscar; Valls Marsal, Joan; Dolcet Roca, Xavier; Vilella, Ramón; Cabiscol Català, Elisa; Matias-Guiu, Xavier; Marti, Rosa M. (Wiley online library, 2016)
      Heat shock proteins (HSPs), are molecular chaperones that assist the proper folding of nascent proteins. This study aims to evaluate the antitumour effects of the hsp90 inhibitor NVP-AUY922 in melanoma, both in vitro ...
    • 2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary 

      Losa, F.; Iglesias, L.; Pané, M.; Sanz, J.; Nieto, B.; Fusté, V.; de la Cruz‑Merino, L.; Concha, Á.; Balañá, Carme; Matias-Guiu, Xavier (Springer, 2018)
      Cancer of unknown primary (CUP) is defned as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They difer from other primary tumours in their ...
    • 7-Bromoindirubin-3'-oxime induces caspase-independent cell death 

      Ribas i Fortuny, Judit; Bettayeb, Karima; Ferandin, Yoan; Knockaert, Marie; Garrofé Ochoa, Xènia; Totzke, Frank; Schächtele, Christoph; Mester, Jan; Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Boix Torras, Jacint; Meijer, Laurent (Nature Publishing Group, 2006)
      Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ...
    • 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death 

      Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José); Garrofé Ochoa, Xènia; Meijer, Laurent; Esquerda Colell, Josep; Boix Torras, Jacint (Elsevier, 2008)
      The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ...
    • 7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome 

      Gou Fàbregas, Myriam; Macià Armengol, Anna; Anerillas Aljama, Carlos; Vaquero, Marta; Jové Font, Mariona; Jain, Sanjay; Ribera i Calvet, Joan; Encinas Martín, Mario (Nature Publishing Group, 2016)
      Smith-Lemli-Opitz syndrome (SLOS) is a rare disorder of cholesterol synthesis. Affected individuals exhibit growth failure, intellectual disability and a broad spectrum of developmental malformations. Among them, renal ...
    • A 3D MRI‐based atlas of a lizard brain 

      Hoops, Daniel; Desfilis, Ester; Ullmann, Jeremy F.P.; Janke, Andrew L.; Stait‐Gardner, Timothy; Devenyi, Gabriel A.; Price, William S.; Medina Hernández, Loreta Mª; Whiting, Martin J.; Keogh, J. Scott (Wiley, 2018)
      Magnetic resonance imaging (MRI) is an established technique for neuroanatomical analysis, being particularly useful in the medical sciences. However, the application of MRI to evolutionary neuroscience is still in its ...
    • A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study 

      Ciudin, Andreea; Fidilio, Enzamaria; Gutiérrez Carrasquilla, Liliana; Caixàs, Assumpta; Vilarrasa, Núria; Pellitero, Silvia; Simó-Servat, Andreu; Vilallonga, Ramón; Ruiz, Amador; de la Fuente, Maricruz; Luna, Alexis; Sánchez, Enric; Rigla, Mercedes; Hernández, Cristina; Salas, Eduardo; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2021)
      Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss ...
    • A common copy-number variant within SIRPB1 correlates with human Out-of-Africa migration after genetic drift correction 

      Royo Sánchez-Palencia, José Luis; Valls Marsal, Joan; Acemel, Rafael D.; Gómez-Marin, Carlos; Pascual Pons, Mariona; Lupiañez, Arantxa; Gomez-Skarmeta, Jose Luis; Fibla Palazón, Joan (Public Library of Science, 2018)
      Previous reports have proposed that personality may have played a role on human Out-Of- Africa migration, pinpointing some genetic variants that were positively selected in the migrating populations. In this work, we ...
    • A Contemporary Picture of Enterococcal Endocarditis 

      Pericàs, Juan M.; Llopis Pérez, Jaime; Muñoz, Patricia; Gálvez Acebal, Juan; Kestler, Martha; Valerio, Maricela; Hernández Meneses, Marta; Goneaga, Miguel A.; Cobo Belaustegui, Manuel; Montejo, Miguel; Ojeda Burgos, Guillermo; Sousa Regueiro, M. Dolores; Alarcón, Aristides de; Ramos Martínez, Antonio; Miró Meda, José M.; GAMES Investigators (Elsevier, 2020-02)
      Background Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. Objectives The purpose of this study was to describe the characteristics and ...
    • A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe 

      Lazarus, Jeffrey V.; Ekstedt, Mattias; Marchesini, Giulio; Mullen, Jillian; Novak, Katja; Pericàs, Juan M.; Roel, Elena; Romero-Gómez, Manuel; Ratziu, Vlad; Tacke, Frank; Cortez-Pinto, Helena; Anstee, Quentin M.; EASL International Liver Foundation NAFLD Policy Review Collaborators (Elsevier, 2020-01)
      Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become an important field of biomedical inquiry. We aimed to determine whether European countries have ...
    • A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease 

      Mota Zamorano, Sonia; González, Luz María; Robles, Nicolás Roberto; Valdivielso Revilla, José Manuel; Cancho, Bárbara; López Gómez, Juan; Gervasini, Guillermo (MDPI, 2021)
      Diabetic kidney disease (DKD) has been pointed out as a prominent cause of chronic andend-stage renal disease (ESRD). There is a genetic predisposition to DKD, although clinically relevantloci are yet to be identified. We ...
    • A Free App for Diagnosing Burnout (BurnOut App): Development Study 

      Gòdia Manonelles, Jordi; Pifarré Montalà, Marc; Vilaplana Mayoral, Jordi; Solsona Tehàs, Francesc; Abella i Pons, Francesc; Calvo, Antoni; Mitjans, Anna; Gonzalez Olmedo, Maria Pau (JMIR Publications, 2022)
      Background: Health specialists take care of us, but who takes care of them? These professionals are the most vulnerable to the increasingly common syndrome known as burnout. Burnout is a syndrome conceptualized as a result ...
    • A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway 

      Romero, Antonia María; Ramos-Alonso, Lucía; Montellá-Manuel, Sandra; García-Martínez, José; Torre Ruiz, M. A. de la; Pérez-Ortín, José E.; Martínez-Pastor, María Teresa; Puig, Sergi (Elsevier, 2019-09)
      Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to ...
    • A low fractional excretion of Phosphate/Fgf23 ratio is associated with severe abdominal Aortic calcification in stage 3 and 4 kidney disease patients 

      Craver Hospital, Lourdes; Dusso Rosso, Adriana; Martínez Alonso, Montserrat; Sarró, Felipe; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (BioMed Central, 2013)
      Background: Vascular calcification (VC) contributes to high mortality rates in chronic kidney disease (CKD). High serum phosphate and FGF23 levels and impaired phosphaturic response to FGF23 may affect VC. Therefore, ...
    • A Machine-Learning Model for Lung Age Forecasting by Analyzing Exhalations 

      Pifarré Montalà, Marc; Tena, Alberto; Clarià Sancho, Francisco; Solsona Tehàs, Francesc; Vilaplana Mayoral, Jordi; Benavides, Arnau; Mas, Lluis; Abella i Pons, Francesc (MDPI, 2022)
      Spirometers are important devices for following up patients with respiratory diseases. These are mainly located only at hospitals, with all the disadvantages that this can entail. This limits their use and consequently, ...
    • A mathematical model for strigolactone biosynthesis in plants 

      Lucido, Abel; Basallo, Oriol; Sorribas Tello, Albert; Marin-Sanguino, Alberto; Vilaprinyo Terré, Ester; Alves, Rui (Frontiers Media, 2022)
      Strigolactones mediate plant development, trigger symbiosis with arbuscular mycorrhizal fungi, are abundant in 80% of the plant kingdom and help plants gain resistance to environmental stressors. They also induce ...
    • A model of protein association based on their hydrophobic and electric interactions 

      Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Public Library of Science, 2014)
      The propensity of many proteins to oligomerize and associate to form complex structures from their constituent monomers, is analyzed in terms of their hydrophobic (H), and electric pseudo-dipole (D) moment vectors. In ...
    • A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers 

      Torres Cabestany, Pascual; Anerillas Aljama, Carlos; Ramírez Núñez, Omar; Encinas Martín, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald; Portero Otín, Manuel (The Company of Biologists, 2022)
      To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ...