Browsing Institut de Recerca Biomèdica de Lleida (IRBLleida) by Subject "Caenorhabditis elegans"

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    • Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation 

      Guerrero-Gómez, David; Mora-Lorca, José Antonio; Sáenz-Narciso, Beatriz; Naranjo-Galindo, Francisco José; Muñoz-Lobato, Fernando; Parrado-Fernández, Cristina; Goikolea, Julen; Cedazo-Minguez, Ángel; Link, Christopher D.; Neri, Christian; Sequedo, María Dolores; Vázquez-Manrique, Rafael P.; Fernández-Suárez, Elena; Goder, Veit; Pane Domenec, Roser; Cabiscol Català, Elisa; Askjaer, Peter; Cabello, Juan; Miranda-Vizuete, Antonio (Springer Nature, 2019)
      In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, ...