Now showing items 1-9 of 9

    • 2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53 

      Mattiolo, Paolo; Barbero-Farran A.; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2014)
      2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ...
    • 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death 

      Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José); Garrofé Ochoa, Xènia; Meijer, Laurent; Esquerda Colell, Josep; Boix Torras, Jacint (Elsevier, 2008)
      The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ...
    • An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death 

      Garcia-Belinchón, Mercè; Sánchez Osuna, María; Martínez Escardó, Laura; Granados-Colomina, Carla; Pascual-Guiral, Sònia; Iglesias-Guimarais, Victoria; Casanelles, Elisenda; Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José) (American Society for Biochemistry and Molecular Biology, 2015)
      Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling ...
    • Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation 

      Mattiolo, Paolo; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2015-12)
      Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ...
    • Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton 

      Barbier, Sardine; Chatre, Laurent; Bras, Marlène; Sancho, Patricia; Roué, Gaël; Virely, Clémence; Yuste Mateos, Víctor J. (Víctor José); Baudet, Sylvie; Rubio, Manuel; Esquerda Colell, Josep; Sarfati, Marika; Merle-Béral, Hélène; Susin, Santos A. (Ferrata Storti Foundation, 2009)
      Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ...
    • Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage 

      Chicote, Javier; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Frontiers Media, 2020-10-15)
      Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. ...
    • Characterization of the Cell Death Process Induced by Staurosporine in Human Neuroblastoma Cell Lines 

      Boix Torras, Jacint; Llecha Cano, Núria; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Elsevier, 1997)
      Staurosporine is a potent and non-specific inhibitor of protein kinases. There is also evidence of staurosporine being a potent inducer of apoptosis. In several human neuroblastoma cell lines (SH-SY5Y, NB69, IMR-5 and ...
    • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

      Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura Ginard, Miguel Francisco; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
      The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
    • The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins 

      Moubarak, Rana S.; Solé Serra, Carme; Pascual, Marta; Gutierrez, Humberto; Llovera i Tomàs, Marta; Pérez García, María José; Gozzelino, Raffaella; Segura Ginard, Miguel Francisco; Iglesias Guimarais, Victoria; Reix, Stéphanie; Soler i Tatché, Rosa Ma.; Davies, Alun M.; Soriano, Eduardo; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2010)
      FLICE-inhibitory protein (FLIP) is an endogenous inhibitor of the signaling pathway triggered by the activation of death receptors. Here, we reveal a novel biological function for the long form of FLIP (FLIP-L) in neuronal ...