Now showing items 1-3 of 3

    • FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons 

      Yamagishi, Satoru; Hampel, Falko; Hata, Katsuhiko; Toro, Daniel del; Schwark, Manuela; Kvachnina, Elena; Bastmeyer, Martin; Yamashita, Toshihide; Tarabykin, Victor; Klein, Rüdiger; Egea Navarro, Joaquim (EMBO Press, 2011)
      Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of ...
    • FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development 

      Fleitas Pérez, Catherine; Marfull Oromí, Pau; Chauhan, Disha; Toro, Daniel del; Peguera, Blanca; Zammou, Bahira; Rocandio Durán, Daniel; Klein, Rüdiger; Espinet Mestre, Carme; Egea Navarro, Joaquim (Society for Neuroscience, 2021)
      Neuron migration is a hallmark of nervous system development that allows gathering of neurons from different origins for assembling of functional neuronal circuits. Cortical inhibitory interneurons arise in the ventral ...
    • FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons 

      Leyva-Díaz, Eduardo; Toro, Daniel del; Menal Castellote, Maria José; Cambray Carner, Serafí; Susín, Rafael; Tessier-Lavigne, Marc; Klein, Rüdiger; Egea Navarro, Joaquim; López-Bendito, Guillermina (Elsevier, 2014)
      Background: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical ...