Now showing items 1-9 of 9

    • Could IL-17A be a novel therapeutic target in diabetic nephropathy? 

      Lavoz, Carolina; Rayego Mateos, Sandra; Orejudo, Macarena; Opazo Rios, Lucas; Marchant, Vanessa; Marquez Exposito, Laura; Tejera Muñoz, Antonio; Navarro González, Juan F.; Droguett, Alejandra; Ortiz, Alberto; Egido, Jesús; Mezzano, Sergio; Rodrigues-Diez, Raul; Ruiz-Ortega, Marta (MDPI, 2020)
      Chronic kidney disease has become a major medical issue in recent years due to its high prevalence worldwide, its association with premature mortality, and its social and economic implications. A number of patients gradually ...
    • Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology 

      Morgado-Pascual, José L.; Marchant, Vanessa; Dolade, Nuria; Rodrigues-Diez, Raul; Suarez-Alvarez, Beatriz; Kerr, Bredford; Valdivielso Revilla, José Manuel; Ruiz-Ortega, Marta; Rayego Mateos, Sandra (Hindawi Publishing Corporation, 2018)
      The growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society. Chronic kidney disease (CKD) is characterized by ...
    • Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis 

      Marquez Exposito, Laura; Lavoz, Carolina; Rodrigues-Diez, Raul; Rayego Mateos, Sandra; Orejudo, Macarena; Cantero-Navarro, Elena; Ortiz, Alberto; Egido, Jesús; Selgas, Rafael; Mezzano, Sergio; Ruiz-Ortega, Marta (Frontiers Media, 2018)
      Chronic kidney disease (CKD) is emerging as an important health problem due to the increase number of CKD patients and the absence of an effective curative treatment. Gremlin has been proposed as a novel therapeutic target ...
    • IL-17A as a potential therapeutic target for patients on peritoneal dialysis 

      Marchant, Vanessa; Tejera Muñoz, Antonio; Marquez Exposito, Laura; Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Tejedor, Lucia; Santos Sanchez, Laura; Egido, Jesús; Valdivielso Revilla, José Manuel; Fraser, Donald J.; López Cabrera, Manuel; Selgas, Rafael; Ruiz-Ortega, Marta (MDPI, 2020)
      Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy ...
    • Interleukin-17A: Potential mediator and therapeutic target in hypertension 

      Rodrigues-Diez, Raul; Tejera Muñoz, Antonio; Orejudo, Macarena; Marquez Exposito, Laura; Santos Sanchez, Laura; Rayego Mateos, Sandra; Cantero-Navarro, Elena; Tejedor, Lucia; Marchant, Vanessa; Ortiz, Alberto; Egido, Jesús; Mezzano, Sergio; Selgas, Rafael; Navarro González, Juan F.; Valdivielso Revilla, José Manuel; Lavoz, Carolina; Ruiz-Ortega, Marta (Elsevier, 2021)
      Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immunesystem, predominantly Th17 and lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and in ...
    • Molecular Mechanisms of Kidney Injury and Repair 

      Rayego Mateos, Sandra; Marquez Exposito, Laura; Rodrigues Díez, Raquel; Sanz, Ana B.; Guiteras, Roser; Dolade, Nuria; Rubio Soto, Irene; Manonelles Montero, Anna; Codina, Sergi; Ortiz, Alberto; Cruzado, Josep M.; Ruiz-Ortega, Marta; Sola, Anna (MDPI, 2022)
      Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney. CKD predisposes to acute ...
    • Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells 

      Morgado-Pascual, José L.; Rayego Mateos, Sandra; Valdivielso Revilla, José Manuel; Ortiz, Alberto; Egido, Jesús; Ruiz-Ortega, Marta (Hindawi Publishing Corporation, 2015)
      Chronic kidney disease is characterized by Vitamin D deficiency and activation of the renin-angiotensin-aldosterone system. Increasing data show that vitamin D receptor agonists (VDRAs) exert beneficial effects in renal ...
    • Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis 

      Bozić Stanojević, Milica; Caus Enríquez, Maite; Rodrigues-Diez, Raul; Pedraza González, Neus; Ruiz-Ortega, Marta; Garí Marsol, Eloi; Gallel Vicente, María del Pilar; Panadés, Maria José; Martinez, Ana; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Nature Publishing Group, 2020)
      Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various functions within the brain; however, its ...
    • Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage 

      Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Morgado-Pascual, José L.; Valentijn, Floris; Valdivielso Revilla, José Manuel; Goldschmeding, Roel; Ruiz-Ortega, Marta (Hindawi Publishing Corporation, 2018)
      Chronickidneydisease (CKD)ischaracterized bypersistent inflammationandprogressive fibrosis,ultimatelyleadingto end-stage renal disease. Although many studies have investigated the factors involved in the progressive deterioration ...