Browsing Institut de Recerca Biomèdica de Lleida (IRBLleida) by Author "Ros Salvador, Joaquim"
Now showing items 1-20 of 33
-
Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides
Tamarit Sumalla, Jordi; Hoogh, Anouk de; Obis Monné, Èlia; Alsina Obiols, David; Cabiscol Català, Elisa; Ros Salvador, Joaquim (Elsevier, 2012)Protein carbonyl detection has been commonly used to analyze the degree of damage to proteins under oxidative stress conditions. Most laboratories rely on derivatization of carbonyl groups with dinitrophenylhydrazine ... -
Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein
Tasheva, Stefka Mincheva; Obis Monné, Èlia; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Oxford University Press, 2014)Friedreich ataxia (FRDA) is a neurodegenerative disease characterized by a decreased expression of the mitochondrial protein frataxin. Major neurological symptoms of the disease are due to degeneration of dorsal root ganglion ... -
Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin
Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2003)Grx5 is a yeast mitochondrial protein involved in iron- sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically charac- terized ... -
Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1
Reverter Branchat, Gemma; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Sorolla Bardají, Maria Alba; Torre Ruiz, M. A. de la; Ros Salvador, Joaquim (Microbiology Society, 2007)Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces cerevisiae, Adh1p is oxidatively modified during ageing and, consequently, its activity becomes ... -
Colorimetric assay for the quantitation of iron in yeast
Tamarit Sumalla, Jordi; Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Ros Salvador, Joaquim (Elsevier Masson, 2006) -
Engineered Trx2p industrial yeast strain protects glycolysis and fermentation proteins from oxidative carbonylation during biomass propagation
Gómez-Pastor, Rocío; Pérez-Torrado, Roberto; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Matallana, Emilia (BioMed Central, 2012)Background: In the yeast biomass production process, protein carbonylation has severe adverse effects since it diminishes biomass yield and profitability of industrial production plants. However, this significant detriment ... -
Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism
Obis Monné, Èlia; Irazusta, Verónica Patricia; Sanchis, Daniel; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2014)Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ... -
Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities
Moreno Cermeño, Armando J.; Obis Monné, Èlia; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (The American Society for Biochemistry and Molecular Biology, 2010)The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects ... -
Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase
Purroy Lledós, Rosa; Medina-Carbonero, Marta; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2020)Friedreich ataxia (FA) is a cardioneurodegenerative disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Previously, we ... -
Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment
Britti, Elena; Delaspre, Fabien; Feldman, Anat; Osborne, Melissa; Greif, Hagar; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley Open Access, 2018)Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ... -
Influencia del manguito de isquemia en la profilaxis antibiótica en prótesis total de rodilla
Prats Gispert, Laura; Valls Marsal, Joan; Ros Salvador, Joaquim; Jover, Alfredo; Pérez Villar, Ferran; Fernández Martínez, José Juan (Elsevier, 2015)Objetivo: Existe evidencia científica grado iv de la importancia que el antibiótico administradopreoperatoriamente tiene en la prevención de la infección protésica.Hay controversia en si la isquemia aplicada en la cirugía ... -
Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon?
Alsina Obiols, David; Purroy, Rosa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (MDPI, 2018)Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of the frataxin gene. ... -
Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins
Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2008)Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ... -
Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1
Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ... -
Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations
Medina Carbonero, Marta; Sanz Alcázar, Arabela; Britti, Elena; Delaspre, Fabien; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Springer; Birkhäuser Verlag, 2022)Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin ... -
Mitochondrial calcium signaling and neurodegenerative diseases
Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press, 2018-11-16)Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium ... -
Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae
Cabiscol Català, Elisa; Bellí i Martínez, Gemma; Tamarit Sumalla, Jordi; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2002)In the present study, we have analyzed the role of the molecular chaperone Hsp60 in protection of Saccharo- myces cerevisiae against oxidative damage. We con- structed mutant strains in which the levels of Hsp60 protein, ... -
Mitochondrial localization of the yeast forkhead factor Hcm1
Rodríguez Colman, Maria José; Ros Salvador, Joaquim; Cabiscol Català, Elisa (MDPI, 2020-12)Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and ... -
Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast
Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ... -
Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae
Cabiscol Català, Elisa; Piulats Combalia, Eva; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2000)We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are ex- posed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aero- bically ...