Now showing items 1-2 of 2

    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Comprehensive constitutional genetic and epigenetic characterization of lynch-like individuals 

      Damaso, Estela; Gonzalez Acosta, Maribel; Vargas Parra, Gardenia; Navarro, Matilde; Balmana, Judith; Ramon y Cajal, Teresa; Tuset, Noemi; Thompson, Bryony A.; Marín, Fàtima; Fernández, Anna; Gómez, Carolina; Velasco, Àngela; Solanes, Ares; Iglesias, Sílvia; Urgel, Gisela; López, Consol; del Valle, Jesús; Campos, Olga; Santacana, Maria; Matias-Guiu, Xavier; Lázaro, Conxi; Valle, Laura; Brunet, Joan; Pineda, Marta; Capella, Gabriel (MDPI, 2020)
      The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive ...