Now showing items 1-8 of 8

    • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

      Eritja Sánchez, Núria; Felip Nogués, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
      The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...
    • Antitumor Effects of Ral-GTPases Downregulation in Glioblastoma. 

      Cemeli, Tània; Guasch Vallés, Marta; Ribes Santolaria, Marina; Ibars Estiarte, Eva Irene; Navaridas Fernández de Bobadilla, Raúl; Dolcet Roca, Xavier; Pedraza González, Neus; Colomina i Gabarrella, Neus; Torres Rosell, Jordi; Ferrezuelo, Francisco; Herreros Danés, Judit; Garí Marsol, Eloi (MDPI, 2022-07-29)
      Glioblastoma (GBM) is the most common tumor in the central nervous system in adults. This neoplasia shows a high capacity of growth and spreading to the surrounding brain tissue, hindering its complete surgical resection. ...
    • ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma 

      Megino-Luque, Cristina; Sisó, Pol; Mota Martorell, Natàlia; Navaridas Fernández de Bobadilla, Raúl; de la Rosa, Inés; Urdanibia, Izaskun; Albertí Valls, Manel; Santacana Espasa, Maria; Pinyol, Miquel; Bonifaci, Núria; Macià Armengol, Anna; Llobet Navàs, David; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Eritja Sánchez, Núria (Federation of European Biochemical Societies; John Wiley & Sons, 2022)
      AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ...
    • ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status 

      Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip Nogués, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel (MDPI, 2021)
      EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG ...
    • Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation 

      Eritja Sánchez, Núria; Navaridas Fernández de Bobadilla, Raúl; Ruiz Mitjana,Anna; Vidal Sabanés, Maria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (MDPI, 2021-10-05)
      TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor promoter for cancerous cells. These contradictory functions of TGF-β are caused by different cellular contexts, including ...
    • Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species 

      Blasco Angulo, Natividad; Beà Tàrrega, Aida; Barés Junqué, Gisel; Girón, Cristina; Navaridas Fernández de Bobadilla, Raúl; Irazoki, Andrea; López-Lluch, Guillermo; Zorzano, Antonio; Dolcet Roca, Xavier; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2020-10-05)
      The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using ...
    • Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition 

      Ruiz Mitjana, Anna; Navaridas Fernández de Bobadilla, Raúl; Vidal Sabanés, Maria; Perramon Güell, Aida; Yeramian Hakim, Andree; Felip Nogués, Isidre; Eritja Sánchez, Núria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Research, 2022)
      The extracellular matrix and the correct establishment of epithelial cell polarity plays a critical role in epithelial cell homeostasis and cell polarity. In addition, loss of tissue structure is a hallmark of carcinogenesis. ...
    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip Nogués, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...