Now showing items 1-9 of 9

    • Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner 

      Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Granado-Serrano, Ana Belén; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Cabré Cucó, Rosanna; Nadal Rey, Gisela; Bellmunt i Curcó, Josepa; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Springer, 2014)
      The implication of lipid peroxidation in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) derive from high abundance of peroxidation- prone polyunsaturated fatty acids in central nervous system ...
    • Effects of aging and methionine restriction on rat kidney metabolome 

      Pradas Barriga, Irene; Jové Font, Mariona; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Mota Martorell, Natàlia; Pamplona Gras, Reinald (MDPI, 2019-11-14)
      Methionine restriction (MetR) in animal models extends maximum longevity and seems to promote renoprotection by attenuating kidney injury. MetR has also been proven to affect several metabolic pathways including lipid ...
    • Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Caro, Pilar; Gomez, José; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Springer Verlag, 2013)
      Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Pamplona Gras, Reinald (MDPI, 2013)
      Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes ...
    • Plasma long-chain free fatty acids predict mammalian longevity 

      Naudí i Farré, Alba; Jové Font, Mariona; Aledo, Juan Carlos; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Nature Publishing Group, 2013)
      determination of their longevity. In the present work, the use of high-throughput technologies allowed us to determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to 120 ...
    • Sixty years old is the breakpoint of human frontal cortex aging 

      Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natàlia; Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
      Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...
    • Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex 

      Cabré Cucó, Rosanna; Jové Font, Mariona; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Dominguez Gonzalez, Mayelin; Obis Monné, Èlia; Berdun, Rebeca; Mota Martorell, Natàlia; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers in Molecular Neurosciencie, 2016)
      Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed ...
    • Succination of protein thiols in human brain aging 

      Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natàlia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
      Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...