Now showing items 1-2 of 2

    • Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia 

      Cuatrecasas, Miriam; Gorostiaga, Iñigo; Riera, Cristina; Saperas, Esteban; Llort, Gemma; Costa, Irmgard; Matias-Guiu, Xavier; Carrato, Cristina; Navarro, Matilde; Pineda, Marta; Dueñas, Núria; Brunet, Joan; Marco, Vicente; Trias, Isabel; Busteros, José Ignacio; Mateu, Gemma; Balaguer, Francesc; Fernández Figueras, María Teresa; Esteller, Manel; Musulén, Eva (MDPI, 2020)
      The use of epithelial cell adhesion molecule (EPCAM) immunohistochemistry (IHC) is not included in the colorectal cancer (CRC) screening algorithm to detect Lynch syndrome (LS) patients. The aim of the present study was ...
    • Comprehensive constitutional genetic and epigenetic characterization of lynch-like individuals 

      Damaso, Estela; Gonzalez Acosta, Maribel; Vargas Parra, Gardenia; Navarro, Matilde; Balmana, Judith; Ramon y Cajal, Teresa; Tuset, Noemi; Thompson, Bryony A.; Marín, Fàtima; Fernández, Anna; Gómez, Carolina; Velasco, Àngela; Solanes, Ares; Iglesias, Sílvia; Urgel, Gisela; López, Consol; del Valle, Jesús; Campos, Olga; Santacana Espasa, Maria; Matias-Guiu, Xavier; Lázaro, Conxi; Valle, Laura; Brunet, Joan; Pineda, Marta; Capellà, Gabriel (MDPI, 2020)
      The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive ...