Now showing items 715-734 of 908

    • Relative amino acid composition signatures of organisms and environments 

      Moura, Alexandra; Savageau, Michael A.; Alves, Rui (Public Library of Science, 2013)
      Background: Identifying organism-environment interactions at the molecular level is crucial to understanding how organisms adapt to and change the chemical and molecular landscape of their habitats. In this work we ...
    • REMOTE ischemic perconditioning among acute ischemic stroke patients in Catalonia: REMOTE-CAT PROJECT 

      Purroy Garcia, Francisco; Arque, Gloria; Mauri-Capdevila, Gerard; García-Vázquez, Cristina; Vicente-Pascual, Mikel; Pereira, Cristina; Vazquez-Justes, Daniel; Torres-Querol, Coral; Vena Martínez, Ana Belén; Abilleira, Sònia; Cardona, Pere; Forné Izquierdo, Carles; Jiménez-Fàbrega, Xavier; Pagola, Jorge; Portero Otín, Manuel; Rodríguez-Campello, Ana; Rovira, Àlex; Fàbregas, Joan Martí (Frontiers Media, 2020)
      Rationale: Remote ischemic perconditioning during cerebral ischemia (RIPerC) refers to the application of brief episodes of transient limb ischemia commonly to a limb, it represents a new safe, simple and low-cost paradigm ...
    • Reporting of methodologic information on trial registries for quality assessment: a study of trial records retrieved from the WHO search portal 

      Reveiz, Ludovic; Chan, An-Wen; Krleza-Jeric, Karmela; Granados, Carlos Eduardo; Pinart, Mariona; Etxeandia, Itziar; Rada, Diego; Martínez Alonso, Montserrat; Bonfill, Xavier; Cardona, Andrés Felipe (Public Library of Science (PLoS), 2010)
      Background: Although randomized clinical trials (RCTs) are considered the gold standard of evidence, their reporting is often suboptimal. Trial registries have the potential to contribute important methodologic information ...
    • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

      van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius Calderó, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
      Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...
    • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

      Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
      Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...
    • Resistant/Refractory Hypertension and Sleep Apnoea: Current Knowledge and Future Challenges 

      Oscullo, Grace; Torres, Gerard; Campos-Rodríguez, Francisco; Posadas, Tomás; Reina-González, Angela; Sapiña Beltrán, Esther; Barbé Illa, Ferran; Martínez-García, Miguel Angel (MDPI, 2019)
      Hypertension is one of the most frequent cardiovascular risk factors. The population of hypertensive patients includes some phenotypes whose blood pressure levels are particularly difficult to control, thus putting them ...
    • Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance 

      Vall-llaura Espinosa, Núria; Reverter Branchat, Gemma; Vived Maza, Celia; Weertman, Naomi; Rodríguez Colman, Maria José; Cabiscol Català, Elisa (Elsevier, 2016)
      The regulatory mechanisms of yeast Sir2, the founding member of the sirtuin family involved in oxidative stress and aging, are unknown. Redox signaling controls many cellular functions, especially under stress situations, ...
    • Risk factors are different for deep and lobar remote hemorrhages after intravenous thrombolysis 

      Prats Sánchez, Luis; Martínez Domeño, Alejandro; Camps Renom, Pol; Delgado Mederos, Raquel; Guisado Alonso, Daniel; Marín, Rebeca; Dorado, Laura; Rudilosso, Salvatore; Gómez González, Alejandra; Purroy Garcia, Francisco; Gómez Choco, Manuel; Cánovas, David; Cocho, Dolores; Garces, Moises; Abilleira i Castells, Sònia; Martí Fàbregas, Joan (Public Library so Science, 2017)
      Remote parenchymal haemorrhage (rPH) after intravenous thrombolysis is defined as hem- orrhages that appear in brain regions without visible ischemic damage, remote from the area of ischemia causing the initial stroke ...
    • Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study 

      Montserrat i Capdevila, Josep; Godoy i García, Pere; Marsal Mora, Josep Ramon; Barbé Illa, Ferran; Galván, Leonardo (BioMed Central, 2015)
      Background: The risk of exacerbation in chronic obstructive pulmonary disease (COPD) depends on the severity of disease and other less well known factors. Predictive models of exacerbation are more accurate than the forced ...
    • Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage 

      Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Morgado-Pascual, José L.; Valentijn, Floris; Valdivielso Revilla, José Manuel; Goldschmeding, Roel; Ruiz-Ortega, Marta (Hindawi Publishing Corporation, 2018)
      Chronickidneydisease (CKD)ischaracterized bypersistent inflammationandprogressive fibrosis,ultimatelyleadingto end-stage renal disease. Although many studies have investigated the factors involved in the progressive deterioration ...
    • S-PC: An e-treatment application for management of smoke-quitting patients 

      Vilaplana Mayoral, Jordi; Solsona Tehàs, Francesc; Abella i Pons, Francesc; Cuadrado, Josep; Alves, Rui; Mateo Fornés, Jordi (Elsevier, 2014)
      The main objective ofthis paper is to present a new program thatfacilitates the management of people who want to quit smoking, implemented through an e-treatment software called S-PC (Smoker Patient Control). S-PC is a ...
    • Saccharomyces cerevisiae as a model organism: a comparative study 

      Karathia, Hiren; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Alves, Rui (Public Library of Science (PLoS), 2011)
      Background: Model organisms are used for research because they provide a framework on which to develop and optimize methods that facilitate and standardize analysis. Such organisms should be representative of the living ...
    • Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases 

      Garcera, Ana; Barreto Parra, Lina Patricia; Piedrafita Llorens, Lídia; Tamarit Sumalla, Jordi; Herrero Perpiñán, Enrique (Biochemical Society, 2006)
      The Saccharomyces cerevisiae genome encodes three proteins that Analysis of point mutants derived from wild-type Gto2 indicates display similarities with human GSTOs (Omega class glutathione that, among the three cysteine ...
    • Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genes 

      Bellí i Martínez, Gemma; Molina Navarro, Maria Micaela; García-Martínez, José; Pérez-Ortín, José E.; Herrero Perpiñán, Enrique (The American Society for Biochemistry and Molecular Biology, 2004)
      The Saccharomyces cerevisiae GRX5 gene codes for a mitochondrial glutaredoxin involved in the synthesis of iron/sulfur clusters. Its absence prevents respiratory growth and causes the accumulation of iron inside cells and ...
    • Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway 

      Izquierdo Álvarez, Alicia; Casas Herranz, Celia; Mühlenhoff, Ulrich; Lillig, Christopher Horst; Herrero Perpiñán, Enrique (American Society for Microbiology, 2008)
      Saccharomyces cerevisiae Grx6 and Grx7 are two monothiol glutaredoxins whose active-site sequences (CSYS and CPYS, respectively) are reminiscent of the CPYC active-site sequence of classical dithiol glutaredoxins. Both ...
    • Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database 

      Real, Jordi; Serna Arnaiz, Catalina; Giner-Soriano, Maria; Forés, Rosa; Pera, Guillem; Ribes, Esther; Alzamora, Maite; Marsal Mora, Josep Ramon; Heras, Antonio; Morros, Rosa (BioMed Central, 2018)
      Background: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events ...
    • Seguimiento y control de pacientes fumadores en proceso de deshabituación mediante SMS. Una experiencia en e-salud 

      Abella i Pons, Francesc; Vilarasau, Assumpció; Cuadrado, Josep; Solsona Tehàs, Francesc; Alves, Rui; Vilaplana Mayoral, Jordi; Serra, Joan (Asociación Española de Estudios en Drogodependencias, 2014)
      El consumo de tabaco continúa siendo una importante causa de morbilidad y mortalidad. El proceso terapéutico para abandonar el tabaco consiste en la desintoxicación física de la nicotina y en el mantenimiento de la abstinencia ...
    • Selenite-induced cell death in Saccharomyces cerevisiae: protective role of glutaredoxins 

      Izquierdo Álvarez, Alicia; Casas Herranz, Celia; Herrero Perpiñán, Enrique (Society for General Microbiology, 2010)
      Unlike in higher organisms, selenium is not essential for growth in Saccharomyces cerevisiae. In this species, it causes toxic effects at high concentrations. In the present study, we show that when supplied as selenite ...
    • Separation of rooster spermatogenic nuclei by means of centrifugal elutriation 

      Boix Torras, Jacint; Roca, Joaquim (Wiley, 1993)
      By application of minor variations in the usual method of centrifugal elutriation, we have been able to separate a nuclear suspension from rooster testes. We have obtained a population of elongated or late spermatid ...
    • Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid 

      Lara Gallego, Beatriz; Martínez, María Teresa; Blanco, Ignacio; Hernández, Cristina; Velasco, Eladio; Ferrarotti, Ilaria; Rodríguez, Francisco; Perez, Laura; Vazquez, Irene; Alonso, Javier; Posada, Manuel; Martínez-Delgado, Beatriz (BioMed Central, 2014)
      [Background]: Severe Alpha-1 Antitrypsin (AAT) deficiency is a hereditary condition caused by mutations in the SERPINA1 gene, which predisposes to lung emphysema and liver disease. It is usually related to PI*Z alleles, ...