Now showing items 417-436 of 913

    • Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis 

      Marquez Exposito, Laura; Lavoz, Carolina; Rodrigues-Diez, Raul; Rayego Mateos, Sandra; Orejudo, Macarena; Cantero-Navarro, Elena; Ortiz, Alberto; Egido, Jesús; Selgas, Rafael; Mezzano, Sergio; Ruiz-Ortega, Marta (Frontiers Media, 2018)
      Chronic kidney disease (CKD) is emerging as an important health problem due to the increase number of CKD patients and the absence of an effective curative treatment. Gremlin has been proposed as a novel therapeutic target ...
    • Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael; Fernández Real, José Manuel (Biomed Central, 2020-04-30)
      Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
    • HBPF: a Home Blood Pressure Framework with SLA guarantees to follow up hypertensive patients 

      Cuadrado, Josep; Vilaplana Mayoral, Jordi; Mateo Fornés, Jordi; Solsona Tehàs, Francesc; Solsona, Sara; Rius Torrentó, Josep Maria; Alves, Rui; Camafort, Miguel; Torres, Gerard; Betriu i Bars, M. Àngels; Gutiérrez Vilaplana, Josep M.; Fernández i Giráldez, Elvira (PeerJ, 2016)
      Hypertension or high blood pressure is a condition on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating it involves exhaustive monitoring of ...
    • Heat shock response in yeast involves changes in both transcription rates and mRNA stabilities 

      Castells i Roca, Laia; García-Martínez, José; Moreno, Joaquín; Herrero Perpiñán, Enrique; Bellí i Martínez, Gemma; Pérez-Ortín, José E. (Public Library of Science (PLoS), 2011)
      We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25uC to 37uC. Using an established mathematical ...
    • Hepatic and Visceral Adipose Tissue 11bHSD1 Expressions are Markers of Body Weight Loss After Bariatric Surgery 

      Pardina, Eva; Baena-Fustegueras, Juan A; Fort, José Manuel; Ferrer, Roser; Rossell, Joana; Esteve, Montserrat; Peinado Onsurbe, Julia; Grasa, Mar (Wiley online library, 2015)
      Cortisolemia and 11βHSD1 in liver and adipose tissue are altered in obesity. However, their participation in the development of obesity remains unclear. This study analyzed these parameters in the transition from morbid ...
    • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

      Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius Calderó, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
      Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
    • High levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease 

      Arcidiacono, Maria V.; Martínez Alonso, Montserrat; Belart, Montserrat; Vilar, Ana; Martín, Marisa; Craver Hospital, Lourdes; Betriu i Bars, M. Àngels; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira; Borràs, Mercè (Hindawi, 2017-01-04)
      Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa ...
    • High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition 

      Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)
      Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
    • High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations 

      Murali, Rajmohan; Davidson, Ben; Fadare, Oluwole; Carlson, Joseph A.; Crum, Christopher; Gilks, C. Blake; Irving, Julie A.; Malpica, Anais; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mittal, Khush; Oliva, Esther; Parkash, Vinita; Rutgers, Joanne; Staats, Paul; Stewart, Colin; Tornos, Carmen; Soslow, Robert A. (Lippincott, Williams & Wilkins, 2019)
      This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International ...
    • Higher Accuracy of Lung Ultrasound over Chest X-ray for Early Diagnosis of COVID-19 Pneumonia 

      Martínez Redondo, Javier; Comas Rodríguez, Carles; Pujol Salud, Jesús; Crespo Pons, Montserrat; García Serrano, Cristina; Ortega Bravo, Marta; Palacín Peruga, Jose María (MDPI, 2021)
      Background: The COVID-19 pandemic rapidly strained healthcare systems worldwide. The reference standard for diagnosis is a positive reverse transcription polymerase chain reaction (RTPCR) test, but results are not immediate ...
    • Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development 

      García Lopez, Margarita; Abellán Ródenas, Antonio; Legaz, Isabel; Rubenstein, John L.R.; Puelles, Luis; Medina Hernández, Loreta Mª (Wiley, 2008)
      The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections ...
    • Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe 

      Cornago Protomártir, Marta; Garcia-Alberich, C.; Blasco Angulo, Natividad; Vall-llaura Espinosa, Núria; Nàger Grifo, Mireia; Herreros Danés, Judit; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Llovera i Tomàs, Marta (Nature Publishing Group, 2014-10-02)
      Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ...
    • Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016 

      Godoy i García, Pere; Torner Gràcia, Núria; Soldevila, Núria; Rius, C.; Jane, M.; Martínez, Ana; Caylà, Joan A.; Domínguez García, Àngela (BioMed Central, 2020)
      Background: In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic ...
    • How is intensive care reimbursed? A review of eight European countries 

      Bittner, Martin-Immanuel; Donnelly, Maria; Van Zanten, Arthur R. H; Andersen, Jakob Steen; Guidet, Bertrand; Trujillano Cabello, Javier; Gardiner, Shane; Fitzpatrick, Gerard; Winter, Bob; Joannidis, Michael; Schmutz, Axel (SpringerOpen, 2013-11)
      Reimbursement schemes in intensive care are more complex than in other areas of healthcare, due to special procedures and high care needs. Knowledge regarding the principles of functioning in other countries can lead to ...
    • Human connections and their roles in the occupational well-being of healthcare professionals: a study on loneliness and empathy 

      Soler González, Jorge; San Martín, Montserrat; Delgado Bolton, Roberto; Vivanco, Luis (Frontiers Media, 2017)
      Human connections are key to the promotion of health and prevention of illness; moreover, illness can cause deterioration of human connections. Healthcare professional–patient relationships are key to ensuring the preservation ...
    • Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus 

      Moreno, R.; Rojas, L.A.; Vilardell, Felip; Cervera Soriano, Vanessa; García-Castro, J.; Fajardo, C. A.; Alemany, R. (Hindawi, 2017)
      Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical ...
    • Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer 

      Granados Principal, Sergio; El-azem, Nuri; Pamplona Gras, Reinald; Ramirez Tortosa, Cesar; Pulido Moran, Mario; Vera Ramirez, Laura; Quiles, Jose L.; Sánchez Rovira, Pedro; Naudí i Farré, Alba; Portero Otín, Manuel; Pérez López, Patricia; Ramírez Tortosa, MCarmen (Elsevier, 2014)
      Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ...
    • Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition 

      Jonsson, Marte; Ragnum, Harald Bull; Julin, Cathinka Halle; Yeramian Hakim, Andree; Clancy, Trevor; Frikstad, Kari-Anne Myrum; Seierstad, Therese; Stokke, Trond; Matias-Guiu, Xavier; Ree, Anne Hansen; Flatmark, Kjersti; Lyng, Heidi (Nature Publishing Group, 2016-10-11)
      Background: Histone deacetylase inhibitors (HDACis) like vorinostat are promising radiosensitisers in prostate cancer, but their effect under hypoxia is not known. We investigated gene expression associated with ...
    • Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea 

      Santamaría Martos, Fernando; Benítez, Iván; Zapater, Andrea; Girón, Cristina; Pinilla, Lucía; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Ortega Delgado, Francisco José; Sánchez de la Torre, Manuel (Public Library of Science, 2019-03-13)
      microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. ...
    • Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling 

      Comas, Jorge; Benfeitas, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Solsona Tehàs, Francesc; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Capell Capell, Teresa; Sandmann, Gerhard; Zhu, Changfu; Christou, Paul; Alves, Rui (Wiley online library, 2016)
      Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ...