Now showing items 377-396 of 912

    • Factors predicting cardiovascular events in chronic kidney disease patients. Role of subclinical atheromatosis extent assessed by vascular ultrasound 

      Valdivielso Revilla, José Manuel; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Arroyo, David; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira (Public Library of Science, 2017)
      Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been ...
    • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

      Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura Ginard, Miguel Francisco; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
      The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
    • FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27 

      Alza, Lía; Nàger Grifo, Mireia; Visa Pretel, Anna; Cantí Nicolás, Carles; Herreros Danés, Judit (MDPI, 2020-04-27)
      Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ...
    • La farmacologia de la coagulació plasmàtica per via oral al segle XXI 

      Boix Torras, Jacint; Ribas i Fortuny, Judit (Col·legi Oficial de Metges de Lleida, 2012)
    • Fear of falling in community-dwelling older adults: A cause of falls, a consequence, or both? 

      Lavedán, Ana; Viladrosa, Maria; Jürschik, Pilar; Botigué, Teresa; Nuin Orrio, Carmen; Masot, Olga; Lavedán, Raquel (Public Library of Science, 2018-03-29)
      Background: Despite the number of studies that have tried to demonstrate that there is an association between previous falls and the fear of falling, the relationship between these two variables remains a matter of ...
    • Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial 

      Pons Rodríguez, Anna; Forné Izquierdo, Carles; Vilaplana Mayoral, Jordi; Cruz Esteve, María Inés; Sánchez-López, Isabel; Reñé Reñé, Mercè; Cazorla, Cristina; Hernández Andreu, Marta; Galindo Ortego, Gisela; Llorens Gabandé, Montserrat; Laza-Vásquez, Celmira; Balaguer Llaquet, Pau; Martínez Alonso, Montserrat; Rué i Monné, Montserrat (BMJ Publishing Group, 2020-12-23)
      Introduction Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of ...
    • First-line bevacizumab and capecitabine-oxaliplatin in elderly patients with mCRC: GEMCAD phase II BECOX study 

      Feliu, Jaume; Salud Salvia, Maria Antonieta; Safont, M. J.; García-Girón, C.; Aparicio, Jorge; Serra, O.; Vera, R.; Casado, Enrique; Jorge, Monica; Escudero, P.; Bosch, Carlos; Bohn, Uriel; Pérez-Carrión, Ramon; Carmona, Alberto; Martínez-Marín, V.; Maurel, Joan (Cancer Research UK, 2014)
      Background: Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the ...
    • FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA 

      Maiques Carlos, Oscar; Cuevas, Dolors; García Dios, Diego Andrés; Coenegrachts, Lieve; Santacana, Maria; Velasco, Ana; Romero, Marta; Gatius Calderó, Sònia; Lambrechts, Diether; Müller, Sven; Pedersen, Hans Christian; Dolcet Roca, Xavier; Amant, Frederic; Matias-Guiu, Xavier (Wiley, 2014)
      Aims: To check the usefulness of a standardized protocol of PTEN FISH in 31 endometrial carcinomas (ECs) in comparison with SNP array (SNPA), multiplex ligation-dependent probe amplification (MLPA), and immunohistochemistry. ...
    • FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons 

      Yamagishi, Satoru; Hampel, Falko; Hata, Katsuhiko; Toro, Daniel del; Schwark, Manuela; Kvachnina, Elena; Bastmeyer, Martin; Yamashita, Toshihide; Tarabykin, Victor; Klein, Rüdiger; Egea Navarro, Joaquim (EMBO Press, 2011)
      Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of ...
    • FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons 

      Leyva-Díaz, Eduardo; Toro, Daniel del; Menal Castellote, Maria José; Cambray Carner, Serafí; Susín, Rafael; Tessier-Lavigne, Marc; Klein, Rüdiger; Egea Navarro, Joaquim; López-Bendito, Guillermina (Elsevier, 2014)
      Background: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical ...
    • Fluid Intake Recommendation Considering the Physiological Adaptations of Adults Over 65 Years: A Critical Review 

      Masot, Olga; Miranda Iglesias, Jessica; Lavedán, Ana; Paraiso Pueyo, Elena; Pascual, Alexandra; Botigué, Teresa (MDPI, 2020-11-04)
      The aim of this critical review was to clarify recommended fluid intake for older people. A literature search of published articles and guidelines on fluid intake recommendations until April 2020 was carried out using ...
    • Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Caro, Pilar; Gomez, José; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Springer Verlag, 2013)
      Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the ...
    • Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism 

      Obis Monné, Èlia; Irazusta, Verónica Patricia; Sanchis, Daniel; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2014)
      Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ...
    • Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities 

      Moreno Cermeño, Armando J.; Obis Monné, Èlia; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (The American Society for Biochemistry and Molecular Biology, 2010)
      The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects ...
    • Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase 

      Purroy Lledós, Rosa; Medina-Carbonero, Marta; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2020)
      Friedreich ataxia (FA) is a cardioneurodegenerative disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Previously, we ...
    • Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment 

      Britti, Elena; Delaspre, Fabien; Feldman, Anat; Osborne, Melissa; Greif, Hagar; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley Open Access, 2018)
      Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ...
    • FRAX tool, the WHO algorithm to predict osteoporotic fractures: the first analysis of its discriminative and predictive ability in the Spanish FRIDEX cohort 

      Azagra, Rafael; Roca, Genís; Encabo, Gloria; Aguyé, Amada; Zwart, Marta; Güell, Sílvia; Puchol, Núria; Gene, Emili; Casado, Enrique; Sancho, Pilar; Solà, Silvia; Torán, Pere; Iglesias, Milagros; Gisbert, Maria Carmen; López-Expósito, Francesc; Pujol Salud, Jesús; Fernandez-Hermida, Yolanda; Puente, Ana; Rosàs, Mireia; Bou, Vicente; Antón, Juan José; Lansdberg, Gustavo; Martín-Sánchez, Juan Carlos; Díez-Pérez, Adolf; Prieto-Alhambra, Daniel (BioMed Central, 2012)
      Background: The WHO has recently published the FRAX tool to determine the absolute risk of osteoporotic fracture at 10 years. This tool has not yet been validated in Spain. Methods/design: A prospective observational ...
    • From seabed to bedside: a review on promising marine anticancer compounds 

      Wang, Edina; Sorolla Bardají, Maria Alba; Gopal Krishnan, Priya Darshini; Sorolla, Anabel (MDPI, 2020)
      The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. ...
    • Functional Connectivity Bias in the Prefrontal Cortex of Psychopaths 

      Contreras-Rodríguez, Oren; Pujol Salud, Jesús; Batalla, Iolanda; Harrison, Ben J.; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Macià, Dídac; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Elsevier, 2015)
      BACKGROUND: Psychopathy is characterized by a distinctive interpersonal style that combines callousunemotional traits with inflexible and antisocial behavior. Traditional emotion-based perspectives link emotional impairment ...
    • Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory 

      García-Casas, Ana; García-Olmo, Dolores C.; García-Olmo, Damián (Baishideng Publishing Group, 2017)
      Metastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism, not yet fully understood. What is almost beyond doubt is that circulatory system is crucial for ...