Now showing items 601-620 of 908

    • Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma 

      Cubillos‑Zapata, Carolina; Martínez‑García, Miguel Ángel; Díaz‑García, Elena; Jaureguizar, Ana; Campos‑Rodríguez, Francisco; Sánchez de la Torre, Manuel; Nagore, Eduardo; Martorell‑Calatayud, Antonio; Hernández Blasco, Luis; Pastor, Esther; Abad-Capa, Jorge; Montserrat, Josep Maria; Cabriada‑Nuño, Valentín; Cano‑Pumarega, Irene; Corral-Peñafiel, Jaime; Arias, Eva; Mediano, Olga; Somoza, María; Dalmau-Arias, Joan; Almendros, Isaac; Farré, Ramon; López‑Collazo, Eduardo; Gozal, David; García Río, Francisco (Nature Research, 2020)
      Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases ...
    • Obesity changes the human gut mycobiome 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Jové Font, Mariona; Rodríguez, M. Mar; Pérez, Daniel; Chaves, Felipe Javier; Esteve, Eduardo; Marin-Garcia, Pablo; Xifra, Gemma; Vendrell, Joan; Ricart, Wifredo; Chacón, Matilde R.; Fernández Real, José Manuel (Nature Publishing Group, 2015)
      The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in ...
    • Obesity, a Diet-Induced Inflammatory Disease 

      Lecube Torelló, Albert; López Cano, Carolina (MDPI, 2019)
    • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Contreras-Rodríguez, Oren; Burokas, Aurelijus; Ortega Sánchez, Juan Antonio; Blasco Solà, Gerard; Coll, Claudia; Biarnés, Carles; Castells Nobau, Anna; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Barretina Ginesta, Jordi; Gich Fullà, Jordi; Pérez Brocal, Vicente; Moya, Andrés; Fernández Real, Xavier; Ramió Torrentà, Lluís; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Maldonado, Rafael; Fernández Real, José Manuel (BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)
      Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ...
    • Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study 

      Arroyo, David; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Vidal Amat, Teresa; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (BioMed Central, 2014)
      Background: Cardiovascular events (CVE) are more prevalent in chronic kidney disease (CKD) than in general population, being the main cause of morbimortality. Specific risk factors related to CKD have been suggested, because ...
    • Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle 

      Mediano, Olga; Romero-Peralta, Sofia; Resano, Pilar; Cano-Pumarega, Irene; Sánchez de la Torre, Manuel; Castillo-García, María; Martínez-Sánchez, Ana Belén; Ortigado, Ana; García-Río, Francisco (MDPI, 2019)
      Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles ...
    • Obstructive sleep apnea: in search of precision 

      Sánchez de la Torre, Manuel; Gozal, David (Taylor & Francis, 2017)
      Introduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that ...
    • Occupational Precariousness of Nursing Staff in Catalonia's Public and Private Nursing Homes 

      Fité Serra, Ana Mari; Gea Sánchez, Montserrat; Alconada Romero, Álvaro; Mateos, José Tomás; Blanco Blanco, Joan; Barallat Gimeno, Eva; Roca Llobet, Judith; Muntaner, Carles (MDPI, 2019-12-05)
      Abstract: Nursing sta who provide care in the nursing homes of Catalonia have more precarious work conditions, including more demanding schedules and work overload, than those in other areas of care. This situation entails ...
    • Ocular Inflammation 

      Huerva, Valentín; Ascaso, Francisco J.; Grzybowski, Andrzej (Hindawi Publishing Corporation, 2015)
    • Olfactory and amygdalar structures of the chicken ventral pallium based on the combinatorial expression patterns of LIM and other developmental regulatory genes 

      Abellán Ródenas, Antonio; Legaz, Isabel; Vernier, Baptiste; Rétaux, Sylvie; Medina Hernández, Loreta Mª (Wiley, 2009)
      We compared the combinatorial expression patterns of several LIM domain-containing regulatory genes in the ventrolateral pallium of mouse and chicken, in order to identify the homologues of the ventral pallial amygdala ...
    • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

      Maiques Carlos, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius Calderó, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
      In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
    • Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae 

      Bellí i Martínez, Gemma; Garí Marsol, Eloi; Aldea, Martí; Herrero Perpiñán, Enrique (Blackwell Science, 2001)
      Moderate hyperosmotic stress on Saccharomyces cerevisiae cells produces a temporary delay at the G1 stage of the cell cycle. This is accompanied by transitory downregulation of CLN1, CLN2 and CLB5 transcript levels, ...
    • Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-Adrenoleukodystrophy 

      Fourcade, Stéphane; Schlüter, Agatha; López Erauskin, Jone; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; García Arumí, Elena; Andreu, Antoni L.; Starkov, Anatoly A.; Pamplona Gras, Reinald; Ferrer, Isidre; Portero Otín, Manuel; Pujol, Aurora (Mary Ann Liebert, Inc., 2011)
      Aims: Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, ...
    • Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Piulats Combalia, Eva; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2000)
      We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are ex- posed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aero- bically ...
    • Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases? 

      Galea, Elena; Launay, Nathalie; Portero Otín, Manuel; Ruiz, Montserrat; Pamplona Gras, Reinald; Aubourg, Patrick; Ferrer, Isidre; Pujol, Aurora (Elsevier, 2012)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder expressed as four disease variants characterized by adrenal insufficiency and graded damage in the nervous system. X-ALD is caused by a loss ...
    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...
    • Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia 

      Holubiec, Mariana Inés; Romero, Juan I.; Suárez, Juan; Portavella, Manuel; Fernández Espejo, Emilio; Blanco Calvo, Eduardo; Galeano, Pablo; Rodríguez de Fonseca, Fernando (Springer Verlag, 2018)
      Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and ...
    • Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells 

      Morgado-Pascual, José L.; Rayego Mateos, Sandra; Valdivielso Revilla, José Manuel; Ortiz, Alberto; Egido, Jesús; Ruiz-Ortega, Marta (Hindawi Publishing Corporation, 2015)
      Chronic kidney disease is characterized by Vitamin D deficiency and activation of the renin-angiotensin-aldosterone system. Increasing data show that vitamin D receptor agonists (VDRAs) exert beneficial effects in renal ...
    • Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) 

      Singh, Naveena; Hirschowitz, Lynn; Zaino, Richard; Alvarado-Cabrero, Isabel; Duggan, Máire; Ali-Fehmi, Rouba; Euscher, Elizabeth; Hecht, Jonathan; Horn, Lars-Christian; Ioffe, Olga; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mikami, Yoshiki; Ordi, Jaume; Parkash, Vinita; Quddus, M. Ruhul; Quick, Charles; Staebler, Annette; Zaloudek, Charles; Nucci, Marisa; Malpica, Anais; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The ...
    • Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression 

      Schoof, Nils; Iles, Mark M.; Bishop, D. Timothy; Newton-Bishop, Julia A.; Barrett, Jennifer H.; GenoMEL consortium (Public Library of Science, 2011)
      Systemic immunosuppression is a risk factor for melanoma, and sunburn-induced immunosuppression is thought to be causal. Genes in immunosuppression pathways are therefore candidate melanoma-susceptibility genes. If variants ...