Now showing items 495-514 of 908

    • L1CAM expression in endometrial carcinomas: an ENITEC collaboration study 

      van der Putten, Louis J. M.; Visser, Nicole C.M.; van de Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colás, Eva; Gil-Moreno, Antonio; Garcia, Angel; Mancebo, Gemma; Alameda, Fransesc; Trovik, Jone; Kopperud, Reidun K.; Huvila, Jutta; Schrauwen, Stefanie; Koskas, Martin; Walker, Francine; Weinberger, Vit; Minar, Lubos; Jandakova, Eva; Snijders, Marc P. L. M.; van den Berg-van Erp, Saskia; Matias-Guiu, Xavier; Salvesen, Helga B.; Amant, Frederic; Massuger, Leon F. A. G.; Pijnenborg, Johanna M. A. (Springer Nature, 2016)
      Background: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic ...
    • L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition 

      Versluis, MAC; Plat, A; de Bruyn, M; Matias-Guiu, Xavier; Trovik, Jone; Krakstad, Camilla; Nijman, Hans W.; Bosse, Tjalling; de Bock, GH; Hollema, H (Springer Verlag, 2018)
      Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis ...
    • Laboratory sample stability. Is it possible to define a consensus stability function? An example of five blood magnitudes 

      Gómez Rioja, Rubén; Martínez Espartosa, Débora; Segovia, Marta; Ibarz Escuer, Mercedes; Llopis, María Antonia; Bauçà, Josep Miquel; Marzana, Itziar; Barba, Nuria; Ventura, Monserrat; García del Pino, Isabel; Puente, Juan José; Caballero, Andrea; Gómez, Carolina; García Álvarez, Ana; Alsina, María Jesús; Álvarez, Virtudes (2018-05-05)
      Background: The stability limit of an analyte in a biological sample can be defined as the time required until a measured property acquires a bias higher than a defined specification. Many studies assessing stability and ...
    • Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome 

      Bueno Díez, Marta; Esteba-Castillo, Susanna; Novell, Ramon; Giménez-Palop, Olga; Coronas, Ramon; Gabau, Elisabeth; Corripio, Raquel; Baena, Neus; Viñas-Jornet, Marina; Guitart, Míriam; Torrents-Rodas, David; Deus Yela, Juan; Pujol, Jesús; Rigla, Mercedes; Caixàs, Assumpta (Public Library of Science, 2016)
      Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (Public Library of Science, 2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Las enfermedades crónicas como prioridad de la vigilancia de la salud pública en España 

      Mayoral, José María; Aragonés Sanz, Nuria; Godoy i García, Pere; Sierra Moros, María José; Cano Portero, Rosa; González Moran, Francisco; Pousa Ortega, Ánxela; Grupo de Vigilancia Epidemiológica de la Sociedad Española de Epidemiología (ElsevierSociedad Española de Salud Pública y Administración Sanitaria, 2016)
      En la actualidad, la vigilancia epidemiológica sigue centrada, en España, en las enfermedades transmisibles incluidas en la lista de enfermedades de declaración obligatoria. Sin embargo, el patrón epidemiológico que dominó ...
    • Las gastroenteritis víricas: un problema de salud pública 

      Domínguez García, Àngela; Godoy i García, Pere; Torner Gràcia, Núria; Cardeñosa, Neus; Martínez, Anna (Ministerio de Sanidad y Consumo, 2009)
      Las gastroenteritis agudas (GA) constituyen un problema de salud importante, pudiendo estar causadas por bacterias, parásitos y virus enteropatógenos, entre los que se han reconocido hasta la actualidad rotavirus, ...
    • Leading Factors for Weight Gain during COVID-19 Lockdown in a Spanish Population: A Cross-Sectional Study 

      Sánchez Peña, Enric; Lecube Torelló, Albert; Bellido, Diego; Monereo, Susana; Malagón, Maria Mar; Tinahones, Francisco José (MDPI, 2021)
      The increase in sedentary behaviors during the COVID-19-induced lockdown may have led to a significant weight gain. To investigate this hypothesis, a representative sample of the Spanish adult population comprising 1000 ...
    • Left carotid adventitial vasa vasorum signal correlates directly with age and with left carotid intima-media thickness in individuals without atheromatous risk factors 

      Arcidiacono, Maria V.; Rubinat, Esther; Borràs, Mercè; Betriu i Bars, M. Àngels; Trujillano Cabello, Javier; Vidal, Teresa; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira (BioMed Central, 2015)
      Objective: The early identification of the onset of subclinical atheromatosis is essential in reducing the high mortality risk from cardiovascular disease (CVD) worldwide. Although carotid intima-media thickness (cIMT) ...
    • Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behaviour, without changing mice longevity. 

      Pamplona Gras, Reinald; Portero Otín, Manuel; Naudí i Farré, Alba; Fuente, Monica de la; Barja, Gustavo; Lopez-Torres, Mónica; Mate, Ianire; Cruces, Julia; Gomez, José; Sánchez-Roman, Ines; Gómez, Alexia (Wiley Open AccessAnatomical Society of Great Britain and Ireland, 2014)
      The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the b1-blocker atenolol increased the amount of the ...
    • Limitations in predicting PAM50 intrinsic subtype and risk of relapse score with Ki67 in estrogen receptor-positive HER2- negative breast cancer 

      Fernandez-Martinez, Aranzazu; Pascual, Tomás; Perrone, Giuseppe; Morales Murillo, Serafín; de la Haba, Juan; González-Rivera, Milagros; Galván, Patricia; Zalfa, Francesca; Amato, Michela; Gonzalez, Lucia; Prats, Miquel; Rojo, Federico; Manso, Luis; Paré, Laia; Alonso, Immaculada; Albanell, Joan; Vivancos, Ana; González, Antonio; Matito, Judit; González, Sonia; Fernandez, Pedro; Adamo, Barbara; Muñoz, Montserrat; Viladot, Margarita; Font, Carme; Aya, Francisco; Vidal, Maria; Caballero, Rosalía; Carrasco, Eva; Altomare, Vittorio; Tonini, Giuseppe; Prat, Aleix; Martin, Miguel (Impact Journals, 2017)
      PAM50/Prosigna gene expression-based assay identifies three categorical risk of relapse groups (ROR-low, ROR-intermediate and ROR-high) in post-menopausal patients with estrogen receptor estrogen receptor-positive (ER+)/ ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidro (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Lipid management in patients with chronic kidney disease 

      Ferro, Charles J.; Mark, Patrick B.; Kanbay, Mehmet; Sarafidis, Pantelis; Heine, Gunnar H.; Rossignol, Patrick; Massy, Ziad A.; Mallamaci, Francesca; Valdivielso Revilla, José Manuel; Malyszko, Jolanta; Verhaar, Marianne C.; Ekart, Robert; Vanholder, Raymond; London, Gerard; Ortiz, Alberto; Zoccali, Carmine (Nature Research, 2018)
      An increased risk of cardiovascular disease, independent of conventional risk factors, is present even at minor levels of renal impairment and is highest in patients with end-stage renal disease (ESRD) requiring dialysis. ...
    • Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis 

      Nogueras Penabad, Lara; Gonzalo Benito, Hugo; Jové Font, Mariona; Sol, Joaquim; Gil-Sánchez, Anna; Hervás, J.V.; Valcheva, Petya; González Mingot, Cristina; Solana Moga, M. José; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Brieva Ruiz, Luis (Nature Publishing Group, 2019-08-05)
      Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ...
    • Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism 

      Gonzalo Benito, Hugo; Brieva Ruiz, Luis; Tatzber, Franz; Jové Font, Mariona; Cacabelos Barral, Daniel; Cassanyé, Anna; Lanau, Lucia; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; González Mingot, Cristina; Hernández, Lourdes; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Portero Otín, Manuel (Wiley, 2012)
      Metabolomic and lipidomic analyses have been used for the profiling of neurodegenerative processes, both in targeted and untargeted approaches. In this work we have applied these techniques to the study of CSF samples of ...
    • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters 

      Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Arola i Ferrer, Lluís; Caimari, Antoni; Bas, Josep M. del; Crescenti, Anna; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford Journals, 2013)
      Aims Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

      Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
      The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...